MEFV innate immuity regulator, pyrin (Q11681842)

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mammalian protein found in Homo sapiens

• marenostrin
• MEFV
• pyrin
• MEFV, pyrin innate immunity regulator
• Mediterranean fever

edit

Language	Label	Description	Also known as
English	MEFV innate immuity regulator, pyrin	mammalian protein found in Homo sapiens	marenostrin MEFV pyrin MEFV, pyrin innate immunity regulator Mediterranean fever

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O15553

part of

Death-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O15553

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O15553

Pyrin

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O15553

Butyrophylin-like, SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

B30.2/SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

B-box-type zinc finger, protein family

1 reference

based on heuristic

inferred from protein domain or family

SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SPRY-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DAPIN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O15553

encoded by

MEFV

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O15553

molecular function

zinc ion binding

determination method

NAS

IEA

2 references

retrieved

8 April 2019

stated in

Alternative splicing at the MEFV locus involved in familial Mediterranean fever regulates translocation of the marenostrin/pyrin protein to the nucleus

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

NAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

metal ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

protein binding

determination method

IPI

6 references

retrieved

8 April 2019

stated in

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IPI

retrieved

8 April 2019

stated in

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IPI

retrieved

8 April 2019

stated in

Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IPI

retrieved

8 April 2019

stated in

Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IPI

retrieved

8 April 2019

stated in

Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IPI

retrieved

8 April 2019

stated in

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IPI

actin binding

determination method

IDA

IEA

2 references

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553

determination method

IEA

retrieved

24 April 2018

stated in

The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553

determination method

IDA

identical protein binding

determination method

IPI

3 references

retrieved

8 April 2019

stated in

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IPI

retrieved

8 April 2019

stated in

Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IPI

retrieved

8 April 2019

stated in

Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IPI

actin binding

determination method

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

retrieved

8 April 2019

stated in

The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IBA

cell component

cytoplasm

determination method

IDA

IEA

2 references

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553

determination method

IEA

retrieved

24 April 2018

stated in

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553

determination method

IDA

cytosol

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

TAS

cell projection

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

ruffle

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

intracellular anatomical structure

determination method

IEA

1 reference

retrieved

10 September 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553

determination method

IEA

microtubule associated complex

determination method

IDA

1 reference

retrieved

24 April 2018

stated in

The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553

determination method

IDA

autophagosome

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

microtubule

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

cytoskeleton

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

cytoplasmic vesicle

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

nucleus

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

retrieved

8 April 2019

stated in

Alternative splicing at the MEFV locus involved in familial Mediterranean fever regulates translocation of the marenostrin/pyrin protein to the nucleus

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IDA

lamellipodium

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

cytoplasm

determination method

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

retrieved

8 April 2019

stated in

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IBA

microtubule associated complex

determination method

IBA

IDA

2 references

retrieved

8 April 2019

stated in

The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IBA

biological process

positive regulation of cysteine-type endopeptidase activity

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IDA

negative regulation of interleukin-1 beta production

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IMP

response to interferon-gamma

determination method

IDA

1 reference

retrieved

24 April 2018

stated in

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553

determination method

IDA

positive regulation of autophagy

determination method

IDA

1 reference

retrieved

24 April 2018

stated in

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553

determination method

IDA

negative regulation of macrophage inflammatory protein 1 alpha production

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IMP

immune system process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

negative regulation of NLRP3 inflammasome complex assembly

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IMP

inflammatory response

determination method

IDA

IEA

2 references

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553

determination method

IEA

retrieved

24 April 2018

stated in

The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15553&geneProductId=UniProtKB:O15553

determination method

IDA

negative regulation of inflammatory response

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IMP

negative regulation of cytokine production involved in inflammatory response

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IMP

negative regulation of interleukin-12 production

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IMP

innate immune response

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

inflammatory response

determination method

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IEA

retrieved

8 April 2019

stated in

The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IBA

positive regulation of autophagy

determination method

IBA

IDA

2 references

retrieved

8 April 2019

stated in

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IBA

response to interferon-gamma

determination method

IBA

IDA

2 references

retrieved

8 April 2019

stated in

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

GOA

curator

UniProt

UniProt protein ID

O15553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15553

determination method

IBA

Gene Atlas image

PBB GE MEFV 208262 x at fs.png
732 × 530; 12 KB

0 references

has part(s)

Butyrophylin-like, SPRY domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O15553

B30.2/SPRY domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O15553

DAPIN domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O15553

SPRY domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O15553

SPRY-associated

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O15553

B-box-type zinc finger

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O15553

Identifiers

RefSeq protein ID

NP_000234

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4210

NP_001185465

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4210

XP_016878725

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4210

UniProt protein ID

O15553

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O15553

Ensembl protein ID

ENSP00000219596

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000219596

ENSP00000438711

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000438711

ENSP00000445079

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000445079

ENSP00000339639

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000339639

ENSP00000437486

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000437486

ENSP00000438611

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000438611

ENSP00000444178

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000444178

ENSP00000444471

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000444471

ENSP00000444615

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000444615

ENSP00000458312

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000458312

ENSP00000460269

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000460269

ENSP00000460551

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000460551

ENSP00000461186

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000461186

PDB structure ID

2WL1

1 reference

stated in

UniProt

UniProt protein ID

O15553

retrieved

9 August 2016

language of work or name

English

2MPC

1 reference

stated in

UniProt

UniProt protein ID

O15553

retrieved

9 August 2016

language of work or name

English

4CG4

1 reference

stated in

UniProt

UniProt protein ID

O15553

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

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Wikibooks(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q11681842&oldid=2022911291"