Brain derived neurotrophic factor (Q123045)

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mammalian protein found in Homo sapiens

• abrineurin
• BDNF
• neurotrophin
• brain-derived neurotrophic factor

edit

Language	Label	Description	Also known as
English	Brain derived neurotrophic factor	mammalian protein found in Homo sapiens	abrineurin BDNF neurotrophin brain-derived neurotrophic factor

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P23560

part of

Cystine-knot cytokine

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P23560

brain-derived neurotrophic factor

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P23560

Nerve growth factor-related, protein family

1 reference

based on heuristic

inferred from protein domain or family

Nerve growth factor conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image of molecular model or crystal lattice model

1BND.png
640 × 480; 72 KB

depicts

ribbon diagram

0 references

Brain-derived neurotrophic factor - PDB id 1BND.png
646 × 551; 194 KB

depicts

space-filling model

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P23560

encoded by

BDNF

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P23560

molecular function

signaling receptor binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IEA

neurotrophin TRKB receptor binding

determination method

IBA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23560&geneProductId=UniProtKB:P23560

determination method

IBA

growth factor activity

determination method

IBA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Molecular cloning of a human gene that is a member of the nerve growth factor family

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P23560

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

protein binding

determination method

IPI

2 references

retrieved

8 April 2019

stated in

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IPI

retrieved

8 April 2019

stated in

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IPI

cell component

cytoplasm

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P23560

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

ISS

perinuclear region of cytoplasm

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P23560

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

ISS

mitochondrion

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IDA

nuclear speck

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IDA

cytoplasmic vesicle

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

extracellular region

determination method

IBA

IEA

TAS

3 references

retrieved

24 April 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23560&geneProductId=UniProtKB:P23560

determination method

TAS

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P23560

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23560&geneProductId=UniProtKB:P23560

determination method

IEA

retrieved

24 April 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23560&geneProductId=UniProtKB:P23560

determination method

IBA

extracellular region

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P23560

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IEA

extracellular space

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

synaptic vesicle

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

axon

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

dendrite

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

biological process

brain-derived neurotrophic factor receptor signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

TAS

negative regulation of neuron apoptotic process

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

synapse assembly

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IDA

cell-cell signaling

determination method

IBA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23560&geneProductId=UniProtKB:P23560

determination method

IBA

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

TAS

collateral sprouting

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IDA

positive regulation of synapse assembly

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IDA

positive regulation of collateral sprouting

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IDA

nervous system development

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Molecular cloning of a human gene that is a member of the nerve growth factor family

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

TAS

axon guidance

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

TAS

negative regulation of myotube differentiation

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

ISS

positive regulation of receptor binding

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IDA

regulation of protein localization to cell surface

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

TAS

regulation of signaling receptor activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IEA

activation of phospholipase C activity

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

TAS

neurotrophin TRK receptor signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

TAS

positive regulation of non-membrane spanning protein tyrosine kinase activity

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

TAS

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

peripheral nervous system development

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

memory

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

nerve development

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

nerve growth factor signaling pathway

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

regulation of neuron differentiation

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

neuron projection morphogenesis

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

modulation of chemical synaptic transmission

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

IBA

positive regulation of neuron projection development

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

ISS

negative regulation of apoptotic signaling pathway

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23560

determination method

ISS

Gene Atlas image

PBB GE BDNF 206382 s at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P23560

1 reference

stated in

Identifiers.org

has part(s)

Nerve growth factor-related

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P23560

Nerve growth factor conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P23560

Identifiers

PatientsLikeMe treatment ID

bdnf

0 references

RefSeq protein ID

NP_001137277

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_001137278

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_001137279

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_001137280

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_001137281

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_001137282

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_001137283

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_001137284

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_001137285

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_001137286

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_001137288

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_001700

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_733927

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_733928

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_733929

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_733930

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

NP_733931

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

XP_011518582

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

627

UniProt protein ID

P23560

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P23560

Encyclopedia of China (Third Edition) ID

129533

0 references

Ensembl protein ID

ENSP00000437138

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000437138

ENSP00000320002

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000320002

ENSP00000349084

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000349084

ENSP00000379302

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000379302

ENSP00000379304

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000379304

ENSP00000379305

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000379305

ENSP00000379307

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000379307

ENSP00000379309

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000379309

ENSP00000389345

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000389345

ENSP00000389564

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000389564

ENSP00000400502

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000400502

ENSP00000414303

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000414303

ENSP00000432035

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000432035

ENSP00000432376

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000432376

ENSP00000432727

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000432727

ENSP00000435564

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000435564

ENSP00000435805

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000435805

ENSP00000433003

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000433003

Freebase ID

/m/02v7qq

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Google Knowledge Graph ID

/g/11bc5dcq15

0 references

Microsoft Academic ID

2778790584

0 references

2909214211

0 references

OpenAlex ID

C2778790584

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1BND

1 reference

stated in

UniProt

UniProt protein ID

P23560

retrieved

4 August 2016

language of work or name

English

1B8M

1 reference

stated in

UniProt

UniProt protein ID

P23560

retrieved

4 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(25 entries)

edit

• arwiki عامل التغذية العصبية المستمد من الدماغ
• bswiki BDNF
• cawiki Factor neurotròfic derivat del cervell
• cywiki BDNF
• dewiki Wachstumsfaktor BDNF
• enwiki Brain-derived neurotrophic factor
• eswiki Factor neurotrófico derivado del cerebro
• etwiki Tserebraalne neurotroofne faktor
• fawiki فاکتور نورون‌زایی مشتق‌شده از مغز
• frwiki Facteur neurotrophique dérivé du cerveau
• hewiki גורם נוירוטרופי מוחי
• huwiki Agyi eredetű neurotróf faktor
• itwiki Fattore neurotrofico cerebrale
• jawiki 脳由来神経栄養因子
• kowiki 뇌유래신경영양인자
• nlwiki BDNF
• plwiki Neurotroficzny czynnik pochodzenia mózgowego
• ptwiki Fator neurotrófico derivado do cérebro
• ruwiki BDNF
• shwiki Neurotrofni moždani faktor
• srwiki Neurotrofni moždani faktor
• svwiki Brain-derived neurotrophic factor
• trwiki Beyin-türevli nörotrofik faktör
• ukwiki BDNF
• zhwiki 脑源性神经营养因子

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

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