Macrophage migration inhibitory factor (Q133582)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14174

macrophage migration inhibitory factor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14174

Macrophage migration inhibitory factor, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

3 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

4 references

8 April 2019

The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

Macrophage migration inhibitory factor (MIF) interacts with Bim and inhibits Bim-mediated apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer

IPI

chemoattractant activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

phenylpyruvate tautomerase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

Macrophage migration inhibitory factor promotes intestinal tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

signaling receptor binding

1 reference

8 April 2019

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

cytokine receptor binding

identical protein binding

IPI

1 reference

8 April 2019

Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

1 reference

17 October 2017

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14174&geneProductId=UniProtKB:P14174

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14174&geneProductId=UniProtKB:P14174

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14174&geneProductId=UniProtKB:P14174

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14174&geneProductId=UniProtKB:P14174

17 October 2017

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14174&geneProductId=UniProtKB:P14174

17 October 2017

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14174&geneProductId=UniProtKB:P14174

1 reference

8 April 2019

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14174&geneProductId=UniProtKB:P14174

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14174&geneProductId=UniProtKB:P14174

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14174&geneProductId=UniProtKB:P14174

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14174&geneProductId=UniProtKB:P14174

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

secretory granule lumen

1 reference

8 April 2019

ficolin-1-rich granule lumen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

1 reference

8 April 2019

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

HDA

extracellular exosome

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of protein phosphorylation

HDA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

1 reference

8 April 2019

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of MAP kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

carboxylic acid metabolic process

1 reference

8 April 2019

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of chemokine (C-X-C motif) ligand 2 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

immune system process

1 reference

8 April 2019

DNA damage response, signal transduction by p53 class mediator

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

negative regulation of mature B cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

negative regulation of gene expression

1 reference

8 April 2019

A proinflammatory cytokine inhibits p53 tumor suppressor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

protein homotrimerization

1 reference

8 April 2019

Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of lipopolysaccharide-mediated signaling pathway

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

cell surface receptor signaling pathway

1 reference

8 April 2019

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of arachidonic acid secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of B cell proliferation

1 reference

8 April 2019

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of prostaglandin secretion involved in immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

prostaglandin biosynthetic process

1 reference

8 April 2019

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

innate immune response

1 reference

8 April 2019

negative regulation of myeloid cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

inflammatory response

1 reference

8 April 2019

cell population proliferation

1 reference

8 April 2019

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of phosphorylation

1 reference

8 April 2019

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of myeloid leukocyte cytokine production involved in immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

regulation of macrophage activation

1 reference

8 April 2019

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of protein kinase A signaling

NAS

1 reference

8 April 2019

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

neutrophil degranulation

1 reference

8 April 2019

interleukin-12-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

negative regulation of macrophage chemotaxis

1 reference

8 April 2019

The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of tumor necrosis factor production

1 reference

8 April 2019

The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

positive regulation of ERK1 and ERK2 cascade

4 references

8 April 2019

The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

MIF signal transduction initiated by binding to CD74

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

8 April 2019

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14174

http://www.uniprot.org/uniprot/P14174.txt?version=189

EC enzyme number

5.3.3.12

1 reference

12 January 2016

exact match

http://purl.uniprot.org/uniprot/P14174

1 reference

Macrophage migration inhibitory factor, conserved site

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14174

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

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4 August 2016

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