Dihydrofolate reductase (Q14819390)

http://www.ebi.ac.uk/interpro/protein/P00375

Dihydrofolate reductase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Dihydrofolate reductase conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

dihydrofolate reductase activity

8 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

An active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

Functional analysis of bacterial artificial chromosomes in mammalian cells: mouse Cdc6 is associated with the mitotic spindle apparatus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

oxidoreductase activity

1 reference

14 February 2019

2 references

translation repressor activity, mRNA regulatory element binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

sequence-specific mRNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

dihydrofolate reductase activity

9 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

10 September 2018

An active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

10 September 2018

Functional analysis of bacterial artificial chromosomes in mammalian cells: mouse Cdc6 is associated with the mitotic spindle apparatus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

3 references

dihydrofolate reductase activity

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

An active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

Functional analysis of bacterial artificial chromosomes in mammalian cells: mouse Cdc6 is associated with the mitotic spindle apparatus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

An active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

An active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

An active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

one-carbon metabolic process

IBA

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

tetrahydrofolate biosynthetic process

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00375&geneProductId=UniProtKB:P00375

positive regulation of nitric-oxide synthase activity

1 reference

14 February 2019

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

regulation of removal of superoxide radicals

IMP

1 reference

14 February 2019

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

negative regulation of translation

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

response to methotrexate

dihydrofolate metabolic process

3 references

3 references

tetrahydrofolate biosynthetic process

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00375

folic acid metabolic process

IBA

3 references

Dihydrofolate reductase domain

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00375

Dihydrofolate reductase conserved site

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00375

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016