3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Q14864142)

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mammalian protein found in Mus musculus

HMG-CoA reductase
Hmgcr
uniprot:Q01237
3-hydroxy-3-methylglutaryl-coenzyme A reductase
3-hydroxy-3-methylglutaryl-CoA reductase

Language	Label	Description	Also known as
English	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	mammalian protein found in Mus musculus	HMG-CoA reductase Hmgcr uniprot:Q01237 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3-hydroxy-3-methylglutaryl-CoA reductase

Statements

1 reference

25 May 2022

UniProt protein ID

Hydroxymethylglutaryl-CoA reductase, metazoan

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01237

Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01237

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01237

Hydroxymethylglutaryl-CoA reductase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01237

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01237

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Sterol-sensing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

hydroxymethylglutaryl-CoA reductase (NADPH) activity

determination method

11 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

24 April 2018

Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

24 April 2018

Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

24 April 2018

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

24 April 2018

Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

24 April 2018

Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

24 April 2018

Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

24 April 2018

ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

24 April 2018

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

24 April 2018

Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

oxidoreductase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

hydroxymethylglutaryl-CoA reductase (NADPH) activity

determination method

12 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

integral component of membrane

determination method

2 references

endoplasmic reticulum membrane

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

peroxisomal membrane

determination method

3 references

endoplasmic reticulum

determination method

3 references

biological process

visual learning

determination method

1 reference

14 February 2019

Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

steroid metabolic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

sterol biosynthetic process

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

determination method

coenzyme A metabolic process

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

lipid metabolism

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

response to nutrient

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

cholesterol metabolic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

negative regulation of MAP kinase activity

determination method

1 reference

14 February 2019

Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

cholesterol biosynthetic process

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

myoblast differentiation

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

response to ethanol

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

steroid biosynthetic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

isoprenoid biosynthetic process

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

negative regulation of protein catabolic process

determination method

1 reference

14 February 2019

Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

negative regulation of protein secretion

determination method

1 reference

14 February 2019

Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

negative regulation of amyloid-beta clearance

determination method

1 reference

14 February 2019

Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

determination method

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01237

Sterol-sensing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01237

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000126087

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000126087

ENSMUSP00000126959

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000126959

ENSMUSP00000128294

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000128294

ENSMUSP00000128642

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000128642

ENSMUSP00000128939

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000128939

ENSMUSP00000132155

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000132155

ENSMUSP00000132749

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000132749

ENSMUSP00000022176

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000022176

Sitelinks

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Multilingual sites(0 entries)

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