GLI-Kruppel family member GLI1 (Q14886456)

http://www.ebi.ac.uk/interpro/protein/P47806

Zinc finger C2H2 superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47806

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

1 reference

9 May 2019

GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

3 references

9 May 2019

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

1 reference

24 April 2018

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47806&geneProductId=UniProtKB:P47806

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

9 May 2019

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Decreased arteriolar density in endothelial nitric oxide synthase knockout mice is due to hypertension, not to the constitutive defect in endothelial nitric oxide synthase enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

1 reference

9 May 2019

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

1 reference

9 May 2019

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Patched1 functions as a gatekeeper by promoting cell cycle progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

proximal/distal pattern formation

biological process

1 reference

9 May 2019

Complementary Gli activity mediates early patterning of the mouse visual system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

pituitary gland development

1 reference

14 February 2019

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

regulation of transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47806&geneProductId=UniProtKB:P47806

1 reference

9 May 2019

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

1 reference

9 May 2019

The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

1 reference

9 May 2019

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47806&geneProductId=UniProtKB:P47806

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

ventral midline development

1 reference

9 May 2019

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

positive regulation of transcription, DNA-templated

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Suppressing Wnt signaling by the hedgehog pathway through sFRP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

regulation of osteoblast differentiation

1 reference

9 May 2019

Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

1 reference

9 May 2019

GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

cerebellar cortex morphogenesis

1 reference

9 May 2019

The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

regulation of hepatocyte proliferation

1 reference

9 May 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

canonical Wnt signaling pathway

IMP

1 reference

9 May 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

smoothened signaling pathway

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

dorsal/ventral pattern formation

1 reference

9 May 2019

Complementary Gli activity mediates early patterning of the mouse visual system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

1 reference

9 May 2019

GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

positive regulation of transcription by RNA polymerase II

TAS

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

9 May 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

positive regulation of cell migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

prostate gland development

ISO

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47806

has part(s)

Zinc finger C2H2-type

1 reference

stated in

InterPro Release 71.0