Aquaporin 4 (Q14902507)

http://www.ebi.ac.uk/interpro/protein/P55088

Aquaporin-like

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55088

Major intrinsic protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

12 September 2018

1 reference

12 September 2018

1 reference

9 May 2019

An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

identical protein binding

IPI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

water channel activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Identification of a molecular target for glutamate regulation of astrocyte water permeability.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

10 September 2018

Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

10 September 2018

Cardiac aquaporin expression in humans, rats, and mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

external side of plasma membrane

IDA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

basal plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

basolateral plasma membrane

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

24 April 2018

Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

24 April 2018

Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

24 April 2018

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

24 April 2018

Vasopressin-dependent coupling between sodium transport and water flow in a mouse cortical collecting duct cell line

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

cell projection membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

protein-containing complex

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

basolateral plasma membrane

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

8 April 2019

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

8 April 2019

Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

8 April 2019

Vasopressin-dependent coupling between sodium transport and water flow in a mouse cortical collecting duct cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

8 April 2019

Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

8 April 2019

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

8 April 2019

Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

8 April 2019

Cardiac aquaporin expression in humans, rats, and mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

integral component of membrane

IBA

3 references

9 May 2019

Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

integral component of plasma membrane

IBA

3 references

9 May 2019

mRNAs encoding aquaporins are present during murine preimplantation development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Identification of a molecular target for glutamate regulation of astrocyte water permeability.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

1 reference

8 April 2019

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Cardiac aquaporin expression in humans, rats, and mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

basolateral plasma membrane

IEA

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Vasopressin-dependent coupling between sodium transport and water flow in a mouse cortical collecting duct cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

1 reference

9 May 2019

Impaired hearing in mice lacking aquaporin-4 water channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

ion transmembrane transport

IMP

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

cellular response to interferon-gamma

IBA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice

renal water absorption

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

IGI

transmembrane transport

1 reference

9 May 2019

3 references

14 February 2019

mRNAs encoding aquaporins are present during murine preimplantation development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

14 February 2019

Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

regulation of vascular endothelial growth factor production

IMP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

carbon dioxide transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

negative regulation of interleukin-1 beta production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

negative regulation of interleukin-6 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

protein homooligomerization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

negative regulation of cell adhesion molecule production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

cellular response to glucose stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

4 references

9 May 2019

mRNAs encoding aquaporins are present during murine preimplantation development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Identification of a molecular target for glutamate regulation of astrocyte water permeability.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

cellular water homeostasis

IDA

1 reference

9 May 2019

Identification of a molecular target for glutamate regulation of astrocyte water permeability.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

3 references

9 May 2019

Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

9 May 2019

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

protein homotetramerization

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

cerebrospinal fluid circulation

ISS

1 reference

9 May 2019

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

Major intrinsic protein, conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0