Bone morphogenetic protein 2 (Q14903156)

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mammalian protein found in Mus musculus
  • bone morphogenetic protein 2
  • Bmp2
  • BMP-2A
  • bone morphogenetic protein 2A
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Language Label Description Also known as
English
Bone morphogenetic protein 2
mammalian protein found in Mus musculus
  • bone morphogenetic protein 2
  • Bmp2
  • BMP-2A
  • bone morphogenetic protein 2A

Statements

molecular function
protein binding
determination method
IPI
8 references
retrieved
8 April 2019
stated in
WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity
GOA
curator
UniProt
UniProt protein ID
P21274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IPI
retrieved
8 April 2019
stated in
PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization
GOA
curator
UniProt
UniProt protein ID
P21274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IPI
retrieved
8 April 2019
stated in
Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo
GOA
curator
UniProt
UniProt protein ID
P21274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IPI
retrieved
8 April 2019
stated in
Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IPI
retrieved
8 April 2019
stated in
A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IPI
retrieved
8 April 2019
stated in
The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IPI
retrieved
8 April 2019
stated in
BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IPI
retrieved
8 April 2019
stated in
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IPI
cell component
biological process
BMP signaling pathway
determination method
IDA
IGI
IEA
ISO
8 references
retrieved
24 April 2018
stated in
Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
determination method
ISO
retrieved
24 April 2018
stated in
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
determination method
IGI
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
determination method
IEA
retrieved
24 April 2018
stated in
C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
24 April 2018
stated in
Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
24 April 2018
stated in
A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
24 April 2018
stated in
Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
24 April 2018
stated in
Akt promotes BMP2-mediated osteoblast differentiation and bone development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
determination method
IDA
osteoblast differentiation
determination method
IDA
IGI
IEA
ISO
8 references
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
ISO
retrieved
8 April 2019
stated in
Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IGI
retrieved
8 April 2019
stated in
Akt promotes BMP2-mediated osteoblast differentiation and bone development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IGI
retrieved
8 April 2019
stated in
SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IGI
retrieved
8 April 2019
stated in
Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IEA
retrieved
8 April 2019
stated in
Akt promotes BMP2-mediated osteoblast differentiation and bone development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
8 April 2019
stated in
Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IDA
IEA
IMP
ISO
10 references
retrieved
8 April 2019
stated in
Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
ISO
retrieved
8 April 2019
stated in
Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
ISO
retrieved
8 April 2019
stated in
Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IMP
retrieved
8 April 2019
stated in
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IEA
retrieved
8 April 2019
stated in
Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
8 April 2019
stated in
Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
8 April 2019
stated in
Molecular mechanisms of cell and tissue interactions during early tooth development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
8 April 2019
stated in
Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
8 April 2019
stated in
Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase expression of the proto-oncogene c-fos in murine osteoblastic MC3T3-E1 cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
BMP signaling pathway
determination method
IBA
IDA
IEA
IGI
ISO
9 references
retrieved
8 April 2019
stated in
Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
ISO
retrieved
8 April 2019
stated in
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IEA
retrieved
8 April 2019
stated in
Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
8 April 2019
stated in
Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
8 April 2019
stated in
A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
8 April 2019
stated in
C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
8 April 2019
stated in
Akt promotes BMP2-mediated osteoblast differentiation and bone development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
determination method
IBA

Identifiers

 
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