Cortactin (Q14906157)

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mammalian protein found in Mus musculus
  • mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)
  • uniprot:Q60598
  • Cttn
  • src substrate cortactin
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Language Label Description Also known as
English
Cortactin
mammalian protein found in Mus musculus
  • mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)
  • uniprot:Q60598
  • Cttn
  • src substrate cortactin

Statements

molecular function
protein binding
determination method
IPI
20 references
retrieved
14 February 2019
stated in
Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape
GOA
curator
UniProt
UniProt protein ID
Q60598
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells
GOA
curator
UniProt
UniProt protein ID
Q60598
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Cortactin regulates cell migration through activation of N-WASP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Src phosphorylation of cortactin enhances actin assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Differential regulation of cortactin and N-WASP-mediated actin polymerization by missing in metastasis (MIM) protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Activation of Arp2/3 complex-mediated actin polymerization by cortactin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Sequential interaction of actin-related proteins 2 and 3 (Arp2/3) complex with neural Wiscott-Aldrich syndrome protein (N-WASP) and cortactin during branched actin filament network formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
retrieved
14 February 2019
stated in
An essential role for cortactin in the modulation of the potassium channel Kv1.2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IPI
cell component
lamellipodium
determination method
IDA
IEA
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q60598
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IEA
retrieved
14 February 2019
stated in
Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape
GOA
curator
UniProt
UniProt protein ID
Q60598
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IDA
retrieved
14 February 2019
stated in
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IDA
retrieved
14 February 2019
stated in
Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IDA
retrieved
14 February 2019
stated in
Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598
determination method
IDA
biological process

Identifiers

 
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