SOS Ras/Rac guanine nucleotide exchange factor 1 (Q14908125)

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mammalian protein found in Mus musculus

son-of-sevenless 1
uniprot:Q62245
Sos1
ras guanine exchange factor
guanine nucleotide releasing factor
son of sevenless homolog 1

Language	Label	Description	Also known as
English	SOS Ras/Rac guanine nucleotide exchange factor 1	mammalian protein found in Mus musculus	son-of-sevenless 1 uniprot:Q62245 Sos1 ras guanine exchange factor guanine nucleotide releasing factor son of sevenless homolog 1

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

protein binding

determination method or standard

12 references

14 February 2019

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

14 February 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

14 February 2019

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

14 February 2019

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

14 February 2019

Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

14 February 2019

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

14 February 2019

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

14 February 2019

The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

14 February 2019

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

14 February 2019

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

14 February 2019

Directed discovery of bivalent peptide ligands to an SH3 domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

14 February 2019

Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

protein heterodimerization activity

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

guanyl-nucleotide exchange factor activity

determination method or standard

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

biological process

regulation of pro-B cell differentiation

determination method or standard

1 reference

14 February 2019

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

hair follicle development

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

heart trabecula morphogenesis

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

roof of mouth development

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

regulation of T cell proliferation

determination method or standard

1 reference

14 February 2019

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

blood vessel morphogenesis

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

epidermal growth factor receptor signaling pathway

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

multicellular organism growth

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

lymphocyte homeostasis

determination method or standard

1 reference

14 February 2019

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

heart morphogenesis

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

B cell homeostasis

determination method or standard

1 reference

14 February 2019

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

eyelid development in camera-type eye

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

regulation of T cell differentiation in thymus

determination method or standard

1 reference

14 February 2019

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

pericardium morphogenesis

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

midbrain morphogenesis

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

cardiac atrium morphogenesis

determination method or standard

1 reference

14 February 2019

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

regulation of Rho protein signal transduction

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

positive regulation of epidermal growth factor receptor signaling pathway

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

positive regulation of Ras protein signal transduction

determination method or standard

1 reference

14 February 2019

Nerve growth factor-dependent activation of the small GTPase Rin

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245

determination method or standard

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000067786

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000067786

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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