H2A.X variant histone (Q14912340)

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mammalian protein found in Mus musculus
  • H2ax
  • histone H2AX
  • H2A histone family, member X
  • histone 5 protein 2ax
  • H2afx
  • histone H2A.x
  • H2a/x
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Language Label Description Also known as
English
H2A.X variant histone
mammalian protein found in Mus musculus
  • H2ax
  • histone H2AX
  • H2A histone family, member X
  • histone 5 protein 2ax
  • H2afx
  • histone H2A.x
  • H2a/x

Statements

molecular function
cell component
XY body
determination method
IDA
12 references
retrieved
14 February 2019
stated in
A mouse speciation gene encodes a meiotic histone H3 methyltransferase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
TOPAZ1, a germ cell specific factor, is essential for male meiotic progression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Localization and regulation of murine Esco2 during male and female meiosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Disruption of CHTF18 causes defective meiotic recombination in male mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Meiotic failure in male mice lacking an X-linked factor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
The mouse polyubiquitin gene Ubb is essential for meiotic progression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12)
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
condensed nuclear chromosome
determination method
IDA
5 references
retrieved
14 February 2019
stated in
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Meiotic cohesin complexes are essential for the formation of the axial element in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Meiosis in mice without a synaptonemal complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
chromatin
determination method
IDA
5 references
retrieved
14 February 2019
stated in
Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Genomic instability in mice lacking histone H2AX
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
nucleus
determination method
IDA
IEA
ISO
14 references
retrieved
14 February 2019
stated in
NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
ISO
retrieved
14 February 2019
stated in
Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P27661
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IEA
retrieved
14 February 2019
stated in
AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX
GOA
curator
UniProt
UniProt protein ID
P27661
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Absence of mDazl produces a final block on germ cell development at meiosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
retrieved
14 February 2019
stated in
Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661
determination method
IDA
biological process

Identifiers

 
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