Kit ligand (Q14912447)

http://www.ebi.ac.uk/interpro/protein/P20826

four-helical cytokine-like, core

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20826

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Stat5 expression is critical for mast cell development and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

1 reference

9 May 2019

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

IPI

growth factor activity

1 reference

9 May 2019

stem cell factor receptor binding

IEA

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

14 February 2019

Akt/PTEN signaling mediates estrogen-dependent proliferation of primordial germ cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

Akt/PTEN signaling mediates estrogen-dependent proliferation of primordial germ cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer

IBA

biological process

germ cell development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

positive regulation of MAP kinase activity

TAS

1 reference

9 May 2019

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

positive regulation of melanocyte differentiation

IGI

1 reference

9 May 2019

Indispensable role of Bcl2 in the development of the melanocyte stem cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

positive regulation of leukocyte migration

1 reference

9 May 2019

Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

positive regulation of hematopoietic stem cell proliferation

1 reference

9 May 2019

Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

negative regulation of mast cell apoptotic process

1 reference

9 May 2019

Stat5 expression is critical for mast cell development and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

positive regulation of Ras protein signal transduction

1 reference

9 May 2019

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

negative regulation of apoptotic process

1 reference

9 May 2019

Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

positive regulation of myeloid leukocyte differentiation

IGI

positive regulation of mast cell proliferation

IGI

2 references

1 reference

9 May 2019

Stat5a is essential for the proliferation and survival of murine mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

neural crest cell migration

1 reference

9 May 2019

Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

extrinsic apoptotic signaling pathway in absence of ligand

1 reference

9 May 2019

Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

ectopic germ cell programmed cell death

1 reference

9 May 2019

Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

regulation of signaling receptor activity

IMP

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

IEA

embryonic hemopoiesis

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20826&geneProductId=UniProtKB:P20826

positive regulation of cell population proliferation

ISO

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

14 February 2019

Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

14 February 2019

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

14 February 2019

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

14 February 2019

Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

14 February 2019

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

14 February 2019

Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

male gonad development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

positive regulation of cell population proliferation

IEA

9 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20826