Multiple endocrine neoplasia 1 (Q14913043)

http://www.ebi.ac.uk/interpro/protein/O88559

1 reference

25 May 2022

1 reference

25 May 2022

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

miR-24 regulates menin in the endocrine pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

protein-macromolecule adaptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

sequence-specific DNA binding

1 reference

8 April 2019

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

protein N-terminus binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

4 references

8 April 2019

Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin prevents liver steatosis through co-activation of peroxisome proliferator-activated receptor alpha

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Tumor suppressor Menin acts as a corepressor of LXRα to inhibit hepatic lipogenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

four-way junction DNA binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 references

8 April 2019

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Characterization of the mouse Men1 gene and its expression during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

histone methyltransferase complex

3 references

8 April 2019

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

protein-containing complex

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression

biological process

leukocyte homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

embryonic skeletal system morphogenesis

1 reference

8 April 2019

Menin is required in cranial neural crest for palatogenesis and perinatal viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

positive regulation of transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

roof of mouth development

1 reference

8 April 2019

Menin is required in cranial neural crest for palatogenesis and perinatal viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

regulation of transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

positive regulation of histone methylation

IEA

1 reference

8 April 2019

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

1 reference

8 April 2019

Menin is required in cranial neural crest for palatogenesis and perinatal viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

maternal process involved in female pregnancy

1 reference

8 April 2019

Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of telomerase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of cell cycle

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

negative regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of osteoblast differentiation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

cellular response to DNA damage stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of JNK cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Menin induces apoptosis in murine embryonic fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

positive regulation of osteoblast differentiation

1 reference

8 April 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

positive regulation of cell differentiation

IGI

1 reference

8 April 2019

Menin is required in cranial neural crest for palatogenesis and perinatal viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

regulation of gene expression

1 reference

8 April 2019

miR-24 regulates menin in the endocrine pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

osteoblast development

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

1 reference

14 February 2019

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

positive regulation of protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of organ growth

1 reference

8 April 2019

Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

response to gamma radiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of cell population proliferation

12 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

Menin is required in cranial neural crest for palatogenesis and perinatal viability

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

24 April 2018

Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

osteoblast fate commitment

1 reference

8 April 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

histone lysine methylation

IGI

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

IBA

chromatin organization

1 reference

8 April 2019

1 reference

8 April 2019

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

type B pancreatic cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of cell-substrate adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

regulation of activin receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

positive regulation of transcription by RNA polymerase II

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

regulation of type B pancreatic cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

response to transforming growth factor beta

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of cell cycle G1/S phase transition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

negative regulation of cell population proliferation

13 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin is required in cranial neural crest for palatogenesis and perinatal viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559

histone lysine methylation

IBA

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559