Heparin binding EGF like growth factor (Q14914534)

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mammalian protein found in Homo sapiens

HBEGF
diphtheria toxin receptor (heparin-binding EGF-like growth factor)
diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)
proheparin-binding EGF-like growth factor
heparin-binding epidermal growth factor

Language	Label	Description	Also known as
English	Heparin binding EGF like growth factor	mammalian protein found in Homo sapiens	HBEGF diphtheria toxin receptor (heparin-binding EGF-like growth factor) diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) proheparin-binding EGF-like growth factor heparin-binding epidermal growth factor

Statements

1 reference

13 November 2019

UniProt protein ID

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

growth factor activity

determination method

3 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

24 April 2018

Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

heparin binding

determination method

3 references

24 April 2018

Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

protein tyrosine kinase activity

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

epidermal growth factor receptor binding

determination method

3 references

8 April 2019

Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

growth factor activity

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

heparin binding

determination method

4 references

8 April 2019

Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

endocytic vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

plasma membrane

determination method

2 references

clathrin-coated endocytic vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

integral component of plasma membrane

determination method

3 references

24 April 2018

Ectodomain shedding of membrane-anchored heparin-binding EGF like growth factor and subcellular localization of the C-terminal fragment in the cell cycle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

24 April 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

extracellular space

determination method

5 references

24 April 2018

Ectodomain shedding of membrane-anchored heparin-binding EGF like growth factor and subcellular localization of the C-terminal fragment in the cell cycle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

24 April 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

24 April 2018

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

extracellular space

determination method

6 references

8 April 2019

Ectodomain shedding of membrane-anchored heparin-binding EGF like growth factor and subcellular localization of the C-terminal fragment in the cell cycle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

integral component of plasma membrane

determination method

4 references

8 April 2019

Ectodomain shedding of membrane-anchored heparin-binding EGF like growth factor and subcellular localization of the C-terminal fragment in the cell cycle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

clathrin-coated vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

biological process

positive regulation of keratinocyte migration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

cell chemotaxis

determination method

1 reference

8 April 2019

CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

wound healing, spreading of epidermal cells

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

positive regulation of cell migration

determination method

1 reference

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

positive regulation of cell growth

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

muscle organ development

determination method

1 reference

8 April 2019

Structural organization and chromosomal assignment of the gene encoding the human heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

positive regulation of smooth muscle cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

regulation of heart contraction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

negative regulation of elastin biosynthetic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

positive regulation of wound healing

determination method

1 reference

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

ERBB2 signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

phosphatidylinositol phosphate biosynthetic process

determination method

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

peptidyl-tyrosine phosphorylation

determination method

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

regulation of cell motility

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

epidermal growth factor receptor signaling pathway

determination method

3 references

10 September 2018

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99075&geneProductId=UniProtKB:Q99075

determination method

epidermal growth factor receptor signaling pathway

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

negative regulation of epidermal growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

membrane organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99075

determination method

Gene Atlas image

PBB GE HBEGF 38037 at fs.png
732 × 530; 10 KB

0 references

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99075

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99075

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000230990

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000230990

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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