MYD88 innate immune signal transduction adaptor (Q1500000)

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mammalian protein found in Homo sapiens

mutant myeloid differentiation primary response 88
myeloid differentiation primary response protein MyD88
MYD88
myeloid differentiation primary response gene 88
MYD88D
myeloid differentiation primary response 88
myeloid differentiation primary response gene (88)

Language	Label	Description	Also known as
English	MYD88 innate immune signal transduction adaptor	mammalian protein found in Homo sapiens	mutant myeloid differentiation primary response 88 myeloid differentiation primary response protein MyD88 MYD88 myeloid differentiation primary response gene 88 MYD88D myeloid differentiation primary response 88 myeloid differentiation primary response gene (88)

Statements

1 reference

13 November 2019

UniProt protein ID

Myeloid differentiation primary response protein MyD88

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99836

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99836

Death-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99836

Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

MyD88, death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

death receptor binding

determination method

1 reference

9 May 2019

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

protein binding

determination method

27 references

9 May 2019

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Functional assessment of the mutational effects of human IRAK4 and MyD88 genes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

The apoptotic signaling pathway activated by Toll-like receptor-2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

MAPPIT analysis of TLR adaptor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Characterization of Pellino2, a substrate of IRAK1 and IRAK4

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

identical protein binding

determination method

8 references

9 May 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

MAPPIT analysis of TLR adaptor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

9 May 2019

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

protein self-association

determination method

1 reference

9 May 2019

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

Toll-like receptor binding

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

plasma membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

endosome membrane

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

determination method

1 reference

4 April 2017

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q99836

determination method

biological process

response to interleukin-1

determination method

1 reference

9 May 2019

Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

immune system process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

negative regulation of apoptotic process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

toll-like receptor signaling pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

cell surface receptor signaling pathway

determination method

1 reference

9 May 2019

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

cellular response to mechanical stimulus

determination method

1 reference

9 May 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

regulation of inflammatory response

determination method

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

positive regulation of interleukin-6 production

determination method

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

toll-like receptor 9 signaling pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

positive regulation of interleukin-17 production

determination method

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

inflammatory response

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

3'-UTR-mediated mRNA stabilization

determination method

1 reference

9 May 2019

Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

positive regulation of interleukin-23 production

determination method

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

defense response to Gram-positive bacterium

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

1 reference

9 May 2019

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

apoptotic process

determination method

1 reference

9 May 2019

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

innate immune response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

type I interferon signaling pathway

determination method

1 reference

9 May 2019

HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

positive regulation of gene expression

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

positive regulation of interleukin-8 production

determination method

1 reference

9 May 2019

Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

defense response to bacterium

determination method

1 reference

9 May 2019

Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

interleukin-1-mediated signaling pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

cellular response to oxidised low-density lipoprotein particle stimulus

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

determination method

1 reference

9 May 2019

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

Toll signaling pathway

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

determination method

Gene Atlas image

PBB GE MYD88 209124 at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/Q99836

1 reference

Identifiers.org

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99836

Toll/interleukin-1 receptor homology (TIR) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99836

MyD88, death domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99836

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000390565

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000390565

ENSP00000417848

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417848

ENSP00000379625

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000379625

ENSP00000389979

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389979

ENSP00000391753

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391753

ENSP00000401399

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401399

ENSP00000496950

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496950

ENSP00000497991

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497991

ENSP00000498321

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000498321

ENSP00000498360

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000498360

ENSP00000499012

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499012

ENSP00000498576

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000498576

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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