CLN3 lysosomal/endosomal transmembrane protein, battenin (Q1500005)

http://www.ebi.ac.uk/interpro/protein/Q13286

InterPro Release 71.0

reference URL

MFS transporter superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/Q13286

InterPro Release 71.0

reference URL

Equilibrative nucleoside transporter family

1 reference

Transporter Classification Database ID

2.A.57.5.8

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

1 reference

13 November 2019

1 reference

13 November 2019

unfolded protein binding

1 reference

8 April 2019

A model for Batten disease protein CLN3: functional implications from homology and mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

4 references

8 April 2019

Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

8 April 2019

Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

8 April 2019

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

8 April 2019

Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

Tissue expression and subcellular localization of CLN3, the Batten disease protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

8 April 2019

Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13286&geneProductId=UniProtKB:Q13286

26 September 2017

Biosynthesis and intracellular targeting of the CLN3 protein defective in Batten disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13286&geneProductId=UniProtKB:Q13286

26 September 2017

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13286&geneProductId=UniProtKB:Q13286

integral component of endoplasmic reticulum membrane

1 reference

8 April 2019

Membrane topology of CLN3, the protein underlying Batten disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

Intracellular trafficking of the JNCL protein CLN3

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

A model for Batten disease protein CLN3: functional implications from homology and mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

Defective intracellular transport of CLN3 is the molecular basis of Batten disease (JNCL)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13286&geneProductId=UniProtKB:Q13286

26 September 2017

CLN3 protein regulates lysosomal pH and alters intracellular processing of Alzheimer's amyloid-beta protein precursor and cathepsin D in human cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13286&geneProductId=UniProtKB:Q13286

26 September 2017

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13286&geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

Tissue expression and subcellular localization of CLN3, the Batten disease protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

8 April 2019

CLN3 protein regulates lysosomal pH and alters intracellular processing of Alzheimer's amyloid-beta protein precursor and cathepsin D in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

8 April 2019

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

8 April 2019

Biosynthesis and intracellular targeting of the CLN3 protein defective in Batten disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

8 April 2019

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

negative regulation of neuron apoptotic process

HDA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

negative regulation of proteolysis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

lysosomal lumen acidification

1 reference

26 September 2017

Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13286&geneProductId=UniProtKB:Q13286

negative regulation of catalytic activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

galactosylceramide metabolic process

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

neuromuscular process controlling balance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

ceramide metabolic process

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

vesicle transport along microtubule

1 reference

8 April 2019

Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

cellular amino acid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

neurotransmitter metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

negative regulation of apoptotic process

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

receptor-mediated endocytosis

1 reference

8 April 2019

Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

lysosomal lumen pH elevation

1 reference

8 April 2019

CLN3 protein regulates lysosomal pH and alters intracellular processing of Alzheimer's amyloid-beta protein precursor and cathepsin D in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

globoside metabolic process

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

glucosylceramide metabolic process

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

autophagosome maturation

1 reference

8 April 2019

protein catabolic process

1 reference

8 April 2019

Batten's disease: clues to neuronal protein catabolism in lysosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

ionotropic glutamate receptor signaling pathway

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

membrane organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13286&geneProductId=UniProtKB:Q13286

lysosome organization

1 reference

26 September 2017

1 reference

8 April 2019

The Batten disease gene product (CLN3p) is a Golgi integral membrane protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

amyloid precursor protein catabolic process

NAS

1 reference

8 April 2019

CLN3 protein regulates lysosomal pH and alters intracellular processing of Alzheimer's amyloid-beta protein precursor and cathepsin D in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

sphingomyelin metabolic process

1 reference

8 April 2019

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13286&geneProductId=UniProtKB:Q13286

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13286&geneProductId=UniProtKB:Q13286

regulation of intracellular pH

IEA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13286

Transporter Classification Database ID

IBA

Gene Atlas image

PBB GE CLN3 209275 s at fs.png
732 × 530; 12 KB

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30 May 2020

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30 May 2020

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13 November 2019

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2.A.57.5.8

2 references

Transporter Classification database

retrieved

13 March 2020