LIM homeobox transcription factor 1 beta (Q15311791)

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mammalian protein found in Mus musculus

LIM homeobox transcription factor 1-beta
LIM homeo box transcription factor 1B
LIM/homeobox protein LMX1B
Lmx1b
LIM/homeobox protein 1.2
LMX-1.2
GENA 191

Language	Label	Description	Also known as
English	LIM homeobox transcription factor 1 beta	mammalian protein found in Mus musculus	LIM homeobox transcription factor 1-beta LIM homeo box transcription factor 1B LIM/homeobox protein LMX1B Lmx1b LIM/homeobox protein 1.2 LMX-1.2 GENA 191

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88609

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, LIM-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

2 references

sequence-specific DNA binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

7 November 2018

Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

DNA-binding transcription factor activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

metal ion binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

RNA polymerase II general transcription initiation factor activity

determination method

1 reference

11 October 2018

Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

14 February 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

protein binding

determination method

1 reference

14 February 2019

LMX1B is part of a transcriptional complex with PSPC1 and PSF.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

1 reference

7 November 2018

Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

determination method

4 references

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

7 November 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

7 November 2018

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

determination method

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

14 February 2019

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

biological process

cerebellum morphogenesis

determination method

1 reference

14 February 2019

Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

dopaminergic neuron differentiation

determination method

3 references

14 February 2019

The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

14 February 2019

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

14 February 2019

Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

olfactory behavior

determination method

1 reference

14 February 2019

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

limb morphogenesis

determination method

1 reference

14 February 2019

Identification of genes controlled by LMX1B in E13.5 mouse limbs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

determination method

1 reference

14 February 2019

Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

locomotory behavior

determination method

1 reference

14 February 2019

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

collagen fibril organization

determination method

1 reference

14 February 2019

LMX1B, a LIM homeodomain class transcription factor, is necessary for normal development of multiple tissues in the anterior segment of the murine eye

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

synapse organization

determination method

1 reference

14 February 2019

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

neuron migration

determination method

1 reference

14 February 2019

Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

determination method

1 reference

14 February 2019

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

multicellular organism development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

trabecular meshwork development

determination method

1 reference

14 February 2019

Lmx1b is required for murine trabecular meshwork formation and for maintenance of corneal transparency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

central nervous system neuron development

determination method

1 reference

14 February 2019

Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

embryonic limb morphogenesis

determination method

1 reference

14 February 2019

LMX1B transactivation and expression in nail-patella syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

regulation of gene expression

determination method

1 reference

14 February 2019

Identification of genes controlled by LMX1B in E13.5 mouse limbs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

camera-type eye development

determination method

cell population proliferation

determination method

1 reference

14 February 2019

Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

dorsal/ventral pattern formation

determination method

1 reference

14 February 2019

LMX1B transactivation and expression in nail-patella syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

midbrain development

determination method

1 reference

14 February 2019

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

7 November 2018

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

7 November 2018

Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

7 November 2018

Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

regulation of intracellular transport

determination method

1 reference

14 February 2019

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

regulation of autophagy

determination method

1 reference

14 February 2019

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

transcription by RNA polymerase II

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88609&geneProductId=UniProtKB:O88609

determination method

neuron differentiation

determination method

3 references

14 February 2019

Lmx1b is essential for the development of serotonergic neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

14 February 2019

Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

positive regulation of transcription by RNA polymerase II

determination method

4 references

14 February 2019

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

14 February 2019

Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

14 February 2019

Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88609

determination method

Homeobox domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88609

Zinc finger, LIM-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88609

Homeobox, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88609

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000043616

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000043616

ENSMUSP00000134944

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000134944

ENSMUSP00000159290

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000159290

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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