Cyclin D1 (Q15311866)

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mammalian protein found in Mus musculus
  • uniprot:P25322
  • G1/S-specific cyclin-D1
  • Ccnd1
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Language Label Description Also known as
English
Cyclin D1
mammalian protein found in Mus musculus
  • uniprot:P25322
  • G1/S-specific cyclin-D1
  • Ccnd1

Statements

molecular function
protein binding
determination method
IPI
15 references
retrieved
9 May 2019
stated in
Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation
GOA
curator
UniProt
UniProt protein ID
P25322
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation
GOA
curator
UniProt
UniProt protein ID
P25322
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
E2F-3B is a physiological target of cyclin A
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Isolation and characterization of cytoplasmic cyclin D1 mutants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Requirement for CDK4 kinase function in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
The EGF receptor is required for efficient liver regeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
retrieved
9 May 2019
stated in
Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
ISO
12 references
retrieved
16 July 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
ISO
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P25322
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
IEA
retrieved
16 July 2018
stated in
Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation
GOA
curator
UniProt
UniProt protein ID
P25322
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
16 July 2018
stated in
Mitotic clonal expansion: a synchronous process required for adipogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
16 July 2018
stated in
Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
16 July 2018
stated in
The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
16 July 2018
stated in
CDK4 is an essential insulin effector in adipocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
16 July 2018
stated in
Patched1 functions as a gatekeeper by promoting cell cycle progression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
16 July 2018
stated in
Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
16 July 2018
stated in
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
ISO
13 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25322
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IEA
retrieved
9 May 2019
stated in
Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation
GOA
curator
UniProt
UniProt protein ID
P25322
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
9 May 2019
stated in
Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
9 May 2019
stated in
Mitotic clonal expansion: a synchronous process required for adipogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
9 May 2019
stated in
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
9 May 2019
stated in
Patched1 functions as a gatekeeper by promoting cell cycle progression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
9 May 2019
stated in
The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
9 May 2019
stated in
Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
9 May 2019
stated in
CDK4 is an essential insulin effector in adipocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IBA
cytoplasm
determination method
IBA
IDA
IEA
ISO
7 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25322
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IEA
retrieved
9 May 2019
stated in
The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
9 May 2019
stated in
CDK4 is an essential insulin effector in adipocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
9 May 2019
stated in
Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322
determination method
IBA
biological process

Identifiers

 
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