Insulin receptor substrate 1 (Q15334111)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

21 June 2018

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

9 references

11 October 2018

Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

53BP2S, interacting with insulin receptor substrates, modulates insulin signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

phosphotyrosine residue binding

IPI

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

transmembrane receptor protein tyrosine kinase adaptor activity

insulin receptor binding

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

protein kinase C binding

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

protein domain specific binding

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

insulin receptor binding

4 references

11 October 2018

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

phosphatidylinositol 3-kinase binding

4 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

1 reference

11 October 2018

Intracellular redistribution of nuclear and nucleolar proteins during differentiation of 32D murine hemopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

1 reference

11 October 2018

Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

3 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

insulin receptor complex

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

intracellular membrane-bounded organelle

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

3 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

positive regulation of fatty acid beta-oxidation

biological process

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

positive regulation of glucose import

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

negative regulation of insulin secretion

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

positive regulation of glycogen biosynthetic process

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

protein kinase B signaling

1 reference

11 October 2018

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

positive regulation of cell migration

IGI

1 reference

11 October 2018

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

1 reference

11 October 2018

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

positive regulation of glucose metabolic process

IMP

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

mammary gland development

1 reference

11 October 2018

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

IGI

lipid catabolic process

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

positive regulation of mesenchymal cell proliferation

1 reference

11 October 2018

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

cellular response to insulin stimulus

IGI

2 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

protein localization to nucleus

IDA

2 references

11 October 2018

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

regulation of gene expression

IDA

1 reference

11 October 2018

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

phosphatidylinositol 3-kinase signaling

IMP

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

positive regulation of phosphorylation

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

response to peptide hormone

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

positive regulation of phosphatidylinositol 3-kinase activity

2 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

negative regulation of insulin receptor signaling pathway

IMP

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

positive regulation of insulin receptor signaling pathway

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

protein heterooligomerization

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

positive regulation of glucagon secretion

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

negative regulation of somatostatin secretion

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

cellular response to angiotensin

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

insulin receptor signaling pathway

3 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569

11 October 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569