Dopamine receptor D2 (Q15335226)

http://www.ebi.ac.uk/interpro/protein/P61168

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

adrenergic receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

dopamine neurotransmitter receptor activity, coupled via Gi/Go

IBA

14 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Antiproliferative role of dopamine: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Neuroprotective role of dopamine against hippocampal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Postnatal ontogeny of dopamine D3 receptors in the mouse brain: autoradiographic evidence for a transient cortical expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Circling behavior exhibited by a transgenic insertional mutant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

The fourth transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Lesions of mouse striatum induced by 6-hydroxydopamine differentially alter the density, rate of synthesis, and level of gene expression of D1 and D2 dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

G protein-coupled receptor activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

signal transducer activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

dopamine neurotransmitter receptor activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

integral component of plasma membrane

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

21 June 2018

Alternative splicing of the dopamine D2 receptor directs specificity of coupling to G-proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Neurons exhibiting dopamine D2 receptor immunoreactivity in the substantia nigra of the mutant weaver mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Neurons exhibiting dopamine D2 receptor immunoreactivity in the substantia nigra of the mutant weaver mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

synaptic vesicle membrane

3 references

8 April 2019

Altered dopamine release and uptake kinetics in mice lacking D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Altered dopamine release and uptake kinetics in mice lacking D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Altered dopamine release and uptake kinetics in mice lacking D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

integral component of postsynaptic membrane

EXP

glutamatergic synapse

3 references

3 references

3 references

integral component of presynaptic membrane

3 references

regulation of sodium ion transport

1 reference

8 April 2019

Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

negative regulation of blood pressure

1 reference

8 April 2019

Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

response to inactivity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

Hyperthermic and lethal effects of methamphetamine: roles of dopamine D1 and D2 receptors

response to amphetamine

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

branching morphogenesis of a nerve

1 reference

8 April 2019

The role of dopamine receptors in regulating the size of axonal arbors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

adenylate cyclase-inhibiting dopamine receptor signaling pathway

7 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

21 June 2018

Alternative splicing of the dopamine D2 receptor directs specificity of coupling to G-proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

21 June 2018

Alternative splicing of the dopamine D2 receptor directs specificity of coupling to G-proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

21 June 2018

Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

21 June 2018

Motor dysfunction in type 5 adenylyl cyclase-null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

1 reference

8 April 2019

Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

positive regulation of multicellular organism growth

IGI

1 reference

8 April 2019

Disruption of the D2 dopamine receptor alters GH and IGF-I secretion and causes dwarfism in male mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

orbitofrontal cortex development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

negative regulation of cell population proliferation

6 references

8 April 2019

Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Antiproliferative role of dopamine: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Absence of dopaminergic control on melanotrophs leads to Cushing's-like syndrome in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Antiproliferative role of dopamine: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

3 references

8 April 2019

Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

4 references

8 April 2019

The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Role of dopamine D1 and D2 receptors in CRF-induced disruption of sensorimotor gating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Accumbal dopamine D2 receptors are important for sensorimotor gating in C3H mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

positive regulation of neuroblast proliferation

1 reference

8 April 2019

Dopamine D2 receptor stimulation promotes the proliferation of neural progenitor cells in adult mouse hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

regulation of dopamine secretion

1 reference

21 June 2018

Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

regulation of long-term neuronal synaptic plasticity

1 reference

8 April 2019

Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

positive regulation of renal sodium excretion

1 reference

8 April 2019

Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

behavioral response to cocaine

1 reference

8 April 2019

Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

response to light stimulus

1 reference

8 April 2019

Impaired light masking in dopamine D2 receptor-null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

adenohypophysis development

1 reference

8 April 2019

Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

adenylate cyclase-activating adrenergic receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

nervous system process involved in regulation of systemic arterial blood pressure

IBA

1 reference

8 April 2019

Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

negative regulation of synaptic transmission, glutamatergic

1 reference

8 April 2019

Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

adult walking behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

2 references

G protein-coupled receptor signaling pathway

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

negative regulation of protein kinase B signaling

1 reference

8 April 2019

Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

regulation of dopamine uptake involved in synaptic transmission

1 reference

8 April 2019

Altered dopamine release and uptake kinetics in mice lacking D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

3 references

8 April 2019

Dopamine D2L receptor knockout mice display deficits in positive and negative reinforcing properties of morphine and in avoidance learning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Dopamine D2 receptors mediate two-odor discrimination and reversal learning in C57BL/6 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

positive regulation of dopamine uptake involved in synaptic transmission

1 reference

8 April 2019

Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

positive regulation of urine volume

1 reference

8 April 2019

Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

circadian regulation of gene expression

1 reference

8 April 2019

Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice

regulation of heart rate

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

4 references

8 April 2019

Potentiation of opioid analgesia in dopamine2 receptor knock-out mice: evidence for a tonically active anti-opioid system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Dopamine D2L receptor knockout mice display deficits in positive and negative reinforcing properties of morphine and in avoidance learning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

negative regulation of cell migration

1 reference

8 April 2019

Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

Dopamine D2L receptor- and age-related reduction in offensive aggression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

response to axon injury

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

behavioral response to ethanol

3 references

8 April 2019

Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

negative regulation of innate immune response

1 reference

8 April 2019

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

cerebral cortex GABAergic interneuron migration

1 reference

8 April 2019

Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

Targeted disruption of the dopamine D(2) and D(3) receptor genes leads to different alterations in the expression of striatal calbindin-D(28k)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

The role of dopamine receptors in regulating the size of axonal arbors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

neuron-neuron synaptic transmission

1 reference

8 April 2019

Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

sensory perception of smell

1 reference

8 April 2019

Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

dopamine metabolic process

1 reference

8 April 2019

Regulation by D2 dopamine receptors of in vivo dopamine synthesis in striata of rats and mice with experimental parkinsonism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

phospholipase C-activating dopamine receptor signaling pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Enhancement of dopamine-induced signaling responses in the forebrain of mice lacking dopamine D3 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

positive regulation of growth hormone secretion

1 reference

8 April 2019

Disruption of the D2 dopamine receptor alters GH and IGF-I secretion and causes dwarfism in male mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

intracellular signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

negative regulation of voltage-gated calcium channel activity

dopamine receptor signaling pathway

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

21 June 2018

Distinct functions of the two isoforms of dopamine D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

19 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Comparative, topographically-based evaluation of behavioural phenotype and specification of D(1)-like:D(2) interactions in a line of incipient congenic mice with D(2) dopamine receptor 'knockout'

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Dopamine D2 receptor knock-out mice are insensitive to the hypolocomotor and hypothermic effects of dopamine D2/D3 receptor agonists

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Motor and associative deficits in D2 dopamine receptor knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Altered GABAergic neurotransmission in mice lacking dopamine D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Rescue of locomotor impairment in dopamine D2 receptor-deficient mice by an adenosine A2A receptor antagonist

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Activity, non-selective attention and emotionality in dopamine D2/D3 receptor knock-out mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

regulation of potassium ion transport

3 references

modulation of chemical synaptic transmission

release of sequestered calcium ion into cytosol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

negative regulation of cytosolic calcium ion concentration

adrenergic receptor signaling pathway

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

adenylate cyclase-inhibiting dopamine receptor signaling pathway

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Motor dysfunction in type 5 adenylyl cyclase-null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

response to toxic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

regulation of neurotransmitter uptake

3 references

8 April 2019

Altered dopamine release and uptake kinetics in mice lacking D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Altered dopamine release and uptake kinetics in mice lacking D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Altered dopamine release and uptake kinetics in mice lacking D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

negative regulation of dopamine receptor signaling pathway

EXP

1 reference

8 April 2019

Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

regulation of synaptic vesicle exocytosis

IGI

5 references

8 April 2019

Altered dopamine release and uptake kinetics in mice lacking D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Altered dopamine release and uptake kinetics in mice lacking D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

8 April 2019

Altered dopamine release and uptake kinetics in mice lacking D2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168

physically interacts with

EXP

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

241

language of work or name

English

retrieved

17 August 2016

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

stated in

InterPro Release 71.0