Lacritin (Q1759126)

mammalian protein found in Homo sapiens

LACRT
extracellular glycoprotein lacritin

Language	Label	Description	Also known as
English	Lacritin	mammalian protein found in Homo sapiens	LACRT extracellular glycoprotein lacritin

Statements

1 reference

13 November 2019

Extracellular glycoprotein lacritin

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9GZZ8

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

1 reference

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

growth factor activity

1 reference

8 April 2019

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

1 reference

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

protein N-terminus binding

1 reference

8 April 2019

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

1 reference

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

1 reference

17 October 2017

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ8&geneProductId=UniProtKB:Q9GZZ8

2 references

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

calcineurin-NFAT signaling cascade

1 reference

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

positive regulation of release of sequestered calcium ion into cytosol

1 reference

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

calcium-mediated signaling

determination method

IDA

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

protein localization to Golgi apparatus

1 reference

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

epithelial structure maintenance

1 reference

8 April 2019

Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

1 reference

8 April 2019

Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IMP

positive regulation of cell population proliferation

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ8&geneProductId=UniProtKB:Q9GZZ8

17 October 2017

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ8&geneProductId=UniProtKB:Q9GZZ8

17 October 2017

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ8&geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

positive regulation of epithelial cell proliferation involved in wound healing

1 reference

8 April 2019

Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

positive regulation of macroautophagy

1 reference

8 April 2019

Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

negative regulation of apoptotic process

1 reference

8 April 2019

Lacritin Salvages Human Corneal Epithelial Cells from Lipopolysaccharide Induced Cell Death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

4 references

8 April 2019

Lacritin and other new proteins of the lacrimal functional unit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

A thermo-responsive protein treatment for dry eyes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

negative regulation of lipopolysaccharide-mediated signaling pathway

1 reference

8 April 2019

Lacritin Salvages Human Corneal Epithelial Cells from Lipopolysaccharide Induced Cell Death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

positive regulation of calcium-mediated signaling

1 reference

8 April 2019

Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

defense response to bacterium

1 reference

8 April 2019

A cleavage-potentiated fragment of tear lacritin is bactericidal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IEA

positive regulation of cell population proliferation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IBA

calcium-mediated signaling

3 references

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IBA

positive regulation of secretion

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IBA

positive regulation of calcineurin-NFAT signaling cascade

1 reference

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

IDA

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

2780411060

0 references

Sitelinks

Wikipedia(4 entries)

dewiki Lacritin
enwiki Lacritin
ttwiki LACRT
ukwiki LACRT

Lacritin (Q1759126)

Statements

Identifiers

Sitelinks

Wikipedia(4 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

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Lacritin (Q1759126)

Statements

Identifiers

Sitelinks

Wikipedia(4 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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