The therapeutic potential of metal-based antimalarial agents: implications for the mechanism of action (Q20906133)

https://api.crossref.org/works/10.1039%2FC2DT12247B

Platinum Compounds: a New Class of Potent Antitumour Agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Shrinking the malaria map: progress and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Protection against malaria by MSP3 candidate vaccine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Design of a phase III multicenter trial to evaluate the efficacy of the RTS,S/AS01 malaria vaccine in children across diverse transmission settings in Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Artemisinin Resistance in Plasmodium falciparum Malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Malaria and other vector-borne infection surveillance in the U.S. Department of Defense Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance program: review of 2009 accomplishments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

The skin stage of malaria infection: biology and relevance to the malaria vaccine effort

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Hemozoin: oil versus water

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Crystallization of synthetic haemozoin (beta-haematin) nucleated at the surface of lipid particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

The neutral lipid composition present in the digestive vacuole of Plasmodium falciparum concentrates heme and mediates β-hematin formation with an unusually low activation energy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Plasmodium hemozoin formation mediated by histidine-rich proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Theories on malarial pigment formation and quinoline action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Structural and morphological characterization of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

A role for linoleic acid in erythrocytes infected with Plasmodium berghei

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Haemozoin (beta-haematin) biomineralization occurs by self-assembly near the lipid/water interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

MALARIAL PIGMENT (SO-CALLED MELANIN): ITS NATURE AND MODE OF PRODUCTION

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

An iron-carboxylate bond links the heme units of malaria pigment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

The structure of malaria pigment beta-haematin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

COMPLEX FORMATION BETWEEN CHLOROQUINE AND FERRIHAEMIC ACID IN VITRO, AND ITS EFFECT ON THE ANTIMALARIAL ACTION OF CHLOROQUINE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Alkylation of heme by the antimalarial drug artemisinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

On the molecular mechanism of chloroquine's antimalarial action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Antimalarial compounds: from bench to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Heme Aggregation inhibitors: antimalarial drugs targeting an essential biomineralization process

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Assessing equivalence of inhaled products

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Heme as trigger and target for trioxane-containing antimalarial drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Toward a novel metal-based chemotherapy against tropical diseases. 2. Synthesis and antimalarial activity in vitro and in vivo of new ruthenium- and rhodium-chloroquine complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Synthesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium(II) complexes of chloroquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Toward a novel metal-based chemotherapy against tropical diseases. 3. Synthesis and antimalarial activity in vitro and in vivo of the new gold-chloroquine complex [Au(PPh3)(CQ)]PF6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Toward a novel metal-based chemotherapy against tropical diseases. 7. Synthesis and in vitro antimalarial activity of new gold-chloroquine complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

4-aminoquinoline analogues and its platinum (II) complexes as antimalarial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Synthesis, characterization and biological activity of trans-platinum(II) complexes with chloroquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Characterisation of synthetic beta-haematin and effects of the antimalarial drugs quinidine, halofantrine, desbutylhalofantrine and mefloquine on its formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

The mechanism of antimalarial action of the ruthenium(II)-chloroquine complex [RuCl(2)(CQ)] (2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

The antimalarial activity of Ru-chloroquine complexes against resistant Plasmodium falciparum is related to lipophilicity, basicity, and heme aggregation inhibition ability near water/n-octanol interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

The mechanism of antimalarial action of [Au(CQ)(PPh(3))]PF(6): structural effects and increased drug lipophilicity enhance heme aggregation inhibition at lipid/water interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Experimental conditions for testing the inhibitory activity of chloroquine on the formation of beta-hematin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Investigations of B- and beta-hematin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Synthesis and antimalarial activity of sulfonamide chalcone derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Bioorganometallic chemistry of ferrocene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Novel ferrocenic artemisinin derivatives: synthesis, in vitro antimalarial activity and affinity of binding with ferroprotoporphyrin IX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Antimalarial quinolones: synthesis, potency, and mechanistic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Synthesis, structure, and biological activity of ferrocenyl carbohydrate conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Probing the role of the covalent linkage of ferrocene into a chloroquine template

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Bisquinoline antimalarials: their role in malaria chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

In vitro activity of ferroquine is independent of polymorphisms in transport protein genes implicated in quinoline resistance in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

The antimalarial ferroquine: from bench to clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

In vitro and in vivo antimalarial activity of ferrochloroquine, a ferrocenyl analogue of chloroquine against chloroquine-resistant malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Susceptibility of human malaria parasites to chloroquine is pH dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Investigation of the redox behavior of ferroquine, a new antimalarial

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Trioxaferroquines as new hybrid antimalarial drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Extended-release niacin or ezetimibe and carotid intima-media thickness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Selection of a trioxaquine as an antimalarial drug candidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Metallocene-based antimalarials: an exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Synthesis and antimalarial activities of rhenium bioorganometallics based on the 4-aminoquinoline structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Synthesis, characterization and antimalarial activity of new chromium arene-quinoline half sandwich complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Metalloantimalarials: targeting of P. falciparum strains with novel iron(III) and gallium(III) complexes of an amine phenol ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

A novel endogenous antimalarial: Fe(II)-protoporphyrin IX alpha (heme) inhibits hematin polymerization to beta-hematin (malaria pigment) and kills malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

In vitro antimalarial activity of a series of cationic 2,2'-bipyridyl- and 1,10-phenanthrolineplatinum(II) benzoylthiourea complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Metalloantimalarials: Synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

Synthesis, Structure and in Vitro Biological Screening of Palladium(II) Complexes of Functionalised Salicylaldimine Thiosemicarbazones as Antimalarial and Anticancer Agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

7 January 2021

Characterization of native falcipain, an enzyme involved in Plasmodium falciparum hemoglobin degradation

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

7 January 2021

The mechanism of pyrimethamine resistance in Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

7 January 2021

The propionate of heme binds N4O2 Schiff base antimalarial drug complexes

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

7 January 2021

Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

7 January 2021

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

7 January 2021

In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine

1 reference

https://api.crossref.org/works/10.1039%2FC2DT12247B

7 January 2021