The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury (Q21089854)

2

Maneesh Sen

Garg

1 reference

14 July 2022

Mousumi Ghosh

3

Mousumi

Ghosh

1 reference

14 July 2022

Lilie Lovera

4

Lilie

Lovera

1 reference

14 July 2022

Michael Lopez

5

Michael

Lopez

1 reference

14 July 2022

Monal Patel

6

Monal

Patel

1 reference

14 July 2022

Jack Louro

7

Jack

Louro

1 reference

14 July 2022

Samik Patel

8

Samik

Patel

1 reference

14 July 2022

Luis Tuesta

9

Luis

Tuesta

1 reference

14 July 2022

Wai-Man Chan

10

Wai-Man

Chan

1 reference

14 July 2022

Damien Daniel Pearse

11

Damien Daniel

Creative Commons Attribution 4.0 International

Pearse

1 reference

14 July 2022

language of work or name

English

0 references

publication date

2012

0 references

published in

PLOS One

0 references

volume

7

0 references

page(s)

e43634

0 references

issue

9

0 references

copyright license

start time

19 September 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Treatment with the phosphodiesterase type-4 inhibitor rolipram fails to inhibit blood--brain barrier disruption in multiple sclerosis

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12 September 2017

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Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury

12 September 2017

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Induction of mmp-9 expression and endothelial injury by oxidative stress after spinal cord injury

12 September 2017

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Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats

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Therapeutic benefit of PDE4 inhibitors in inflammatory diseases.

12 September 2017

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Review of clinical trials of neuroprotection in acute spinal cord injury.

12 September 2017

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Delayed Nogo receptor therapy improves recovery from spinal cord contusion

12 September 2017

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Methylprednisolone and other confounders to spinal cord injury clinical trials

12 September 2017

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Inflammatory and apoptotic signaling after spinal cord injury

12 September 2017

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12 September 2017

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Inflammation and apoptosis: linked therapeutic targets in spinal cord injury

12 September 2017

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The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery

12 September 2017

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Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.

12 September 2017

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Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury

12 September 2017

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12 September 2017

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Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events.

12 September 2017

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Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma

12 September 2017

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Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs

12 September 2017

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Targeting the host inflammatory response in traumatic spinal cord injury

12 September 2017

1 reference

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Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses

12 September 2017

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In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting

12 September 2017

1 reference

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PDE4 cAMP-specific phosphodiesterases

12 September 2017

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Rolipram reduces excitotoxic neuronal damage

12 September 2017

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Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole.

12 September 2017

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Role of glutamatergic and GABAergic systems in alcoholism

12 September 2017

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Inflammation contributes to the postponed ischemic neuronal damage following treatment with a glutamate antagonist in rats

12 September 2017

1 reference

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The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3. Consequences for altered intracellular distribution

12 September 2017

1 reference

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Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action

12 September 2017

1 reference

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Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes

12 September 2017

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cAMP-dependent growth cone guidance by netrin-1.

12 September 2017

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Neuronal and glial apoptosis after traumatic spinal cord injury.

12 September 2017

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Paradoxical effects of acute ethanolism in experimental brain injury

12 September 2017

1 reference

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Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor

12 September 2017

1 reference

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Phosphodiesterase inhibitors: new opportunities for the treatment of asthma

12 September 2017

1 reference

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Antioxidant effects in brain and spinal cord injury

12 September 2017

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A monitored contusion model of spinal cord injury in the rat

12 September 2017

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Attenuation of MPTP neurotoxicity by rolipram, a specific inhibitor of phosphodiesterase IV.

12 September 2017

1 reference

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Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.

27 September 2017

1 reference

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Histopathological and behavioral characterization of a novel cervical spinal cord displacement contusion injury in the rat.

27 September 2017

1 reference

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Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors

27 September 2017

1 reference

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Interaction between prostaglandins and calcium: The importance of bell-shaped dose-response curves

27 September 2017

1 reference

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Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1.

27 September 2017

1 reference

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Neuroprotective preconditioning of rat brain cultures with ethanol: potential transduction by PKC isoforms and focal adhesion kinase upstream of increases in effector heat shock proteins

27 September 2017

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Systemic administration of rolipram increases medullary and spinal cAMP and activates a latent respiratory motor pathway after high cervical spinal cord injury

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats

30 May 2018

1 reference

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NT-3, but not BDNF, prevents atrophy and death of axotomized spinal cord projection neurons.

30 May 2018

1 reference

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The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions

30 May 2018

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Noradrenergic activity differentially regulates the expression of rolipram-sensitive, high-affinity cyclic AMP phosphodiesterase (PDE4) in rat brain.

30 May 2018

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Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Neurotropic effects of the optical isomers of the selective adenosine cyclic 3′,5′-monophosphate phosphodiesterase inhibitor rolipram in rats in-vivo

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Recovery of motor function after spinal-cord injury--a randomized, placebo-controlled trial with GM-1 ganglioside

30 May 2018

1 reference

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Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury.

30 May 2018

1 reference

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Combination of olfactory ensheathing cells with local versus systemic cAMP treatment after a cervical rubrospinal tract injury.

29 November 2018

1 reference

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Potential benefits of high-dose methylprednisolone in acute spinal cord injuries

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Systemic hypothermia improves histological and functional outcome after cervical spinal cord contusion in rats.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Schwann cell transplantation improves reticulospinal axon growth and forelimb strength after severe cervical spinal cord contusion.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Beneficial effects of rolipram in a quinolinic acid model of striatal excitotoxicity

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

cAMP regulates axon outgrowth and guidance during optic nerve regeneration in goldfish

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Survival, integration, and axon growth support of glia transplanted into the chronically contused spinal cord

29 November 2018

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Transplantation of Schwann cells and olfactory ensheathing glia after spinal cord injury: does pretreatment with methylprednisolone and interleukin-10 enhance recovery?

29 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury

29 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers.

29 November 2018

1 reference

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Association between inflammation and nigral neuronal damage following striatal excitotoxic lesion

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Comparison of iNOS inhibition by antisense and pharmacological inhibitors after spinal cord injury

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Pilot Dose-Escalation Study of Caffeine Plus Ethanol (Caffeinol) in Acute Ischemic Stroke

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: preclinical experience

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: Curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Jugular vein catheterization for repeated blood sampling in the unrestrained conscious rat.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Activation of the mitogen-activated protein kinase (ERK(1/2)) signaling pathway by cyclic AMP potentiates the neuroprotective effect of the neurotransmitter noradrenaline on dopaminergic neurons

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Jun, Fos and Krox in the thalamus after C-fiber stimulation: coincident-input-dependent expression, expression across somatotopic boundaries, and nucleolar translocation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Characterization of the rolipram-sensitive, cyclic AMP-specific phosphodiesterases: identification and differential expression of immunologically distinct forms in the rat brain

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Delayed treatment with rolipram protects against neuronal damage following global ischemia in rats.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

alpha-Tocopherol attenuates alcohol-induced cerebral vascular damage in rats: possible role of oxidants in alcohol brain pathology and stroke.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Expression of the APC tumor suppressor protein in oligodendroglia.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Emetic, central nervous system, and pulmonary activities of rolipram in the dog.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Axonal regeneration into Schwann cell-seeded guidance channels grafted into transected adult rat spinal cord.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446989

Riluzole and methylprednisolone combined treatment improves functional recovery in traumatic spinal cord injury

29 November 2018

1 reference

12 December 2020

Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells

1 reference

12 December 2020

Delayed treatment of spinal cord injury with erythropoietin or darbepoetin--a lack of neuroprotective efficacy in a contusion model of cord injury

1 reference

12 December 2020

The macrophage in acute neural injury: changes in cell numbers over time and levels of cytokine production in mammalian central and peripheral nervous systems

1 reference

12 December 2020

Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site

1 reference

12 December 2020

Cytokine chemokine expression in contused rat spinal cord

1 reference

12 December 2020

Cellular changes during repair of a cryogenic spinal cord injury in the rat: an electron microscopic study

1 reference

12 December 2020

The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

1 reference

12 December 2020

Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys

1 reference

12 December 2020

Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia

1 reference

12 December 2020

The efficacy of erythropoietin on acute spinal cord injury. An experimental study on a rat model

1 reference

12 December 2020

Nerve fibres in spinal cord impact injuries. Part 1. Changes in the myelin sheath during the initial 5 weeks

1 reference

12 December 2020

The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity

1 reference

12 December 2020

Surgically Induced Cryptorchidism-Related Degenerative Changes in Spermatogonia Are Associated with Loss of Cyclic Adenosine Monophosphate-Dependent Phosphodiesterases Type 4 in Abdominal Testes of Rats

1 reference

12 December 2020

Formation of adenosine-3,5-phosphate (cyclic adenylate) and its relation to the action of several neurohormones or hormones

1 reference

12 December 2020

Anti-inflammatory and analgesic effects of the phosphodiesterase 4 inhibitor rolipram in a rat model of arthritis

1 reference

12 December 2020

Noradrenergic lesions differentially alter the expression of two subtypes of low Km cAMP-sensitive phosphodiesterase type 4 (PDE4A and PDE4B) in rat brain

1 reference

12 December 2020

Combination of low dose ethanol and caffeine protects brain from damage produced by focal ischemia in rats

1 reference

12 December 2020

Increased spinal c-Fos expression with noxious and non-noxious peripheral stimulation after severe spinal contusion

1 reference

12 December 2020

Estimation of nuclear population from microtome sections

1 reference

12 December 2020

Morphologic differentiation of mouse neuroblastoma cells induced in vitro by dibutyryl adenosine 3':5'-cyclic monophosphate

1 reference

12 December 2020

The toxicity of repeated exposures to rolipram, a type IV phosphodiesterase inhibitor, in rats

1 reference

12 December 2020

Improved sensorimotor function by rolipram following focal cerebral ischemia in rats

1 reference

12 December 2020

Therapeutic potential of phosphodiesterase type 4 inhibition in chronic autoimmune demyelinating disease

1 reference

12 December 2020