Methods of blinding in reports of randomized controlled trials assessing pharmacologic treatments: a systematic review (Q21090146)

8 August 2022

1

Isabelle Boutron

Isabelle

Boutron

1 reference

8 August 2022

7

Philippe Ravaud

Philippe

Ravaud

1 reference

17076559

8 August 2022

Candice Poels-Estellat

2

Candice Estellat

Candice

Estellat

1 reference

8 August 2022

4

Agnes

Dechartres

Agnes Dechartres

1 reference

8 August 2022

3

Lydia

Guittet

Lydia Guittet

1 reference

8 August 2022

David L Sackett

5

David L

Sackett

1 reference

17076559

Creative Commons Attribution 4.0 International

8 August 2022

language of work or name

English

0 references

publication date

October 2006

0 references

1 October 2006

2 references

19 September 2019

22 August 2022

2 references

19 September 2019

22 August 2022

3

0 references

issue

10

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page(s)

e425

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copyright license

2 references

Europe PubMed Central

19 September 2019

Comparison of descriptions of allocation concealment in trial protocols and the published reports: cohort study

Europe PubMed Central

22 August 2022

0 references

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Assessing the quality of reports of randomized clinical trials: is blinding necessary?

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

The revised CONSORT statement for reporting randomized trials: explanation and elaboration

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Bias in clinical intervention research.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

A review of blinding in randomized controlled trials found results inconsistent and questionable

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

The ethics of placebo-controlled trials: a comparison of inert and active placebo controls.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Infliximab improves signs and symptoms of psoriatic arthritis: results of the IMPACT 2 trial

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Turning a blind eye: the success of blinding reported in a random sample of randomised, placebo controlled trials

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

What are the main methodological problems in the estimation of placebo effects?

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Analgesic effects of intravenous lidocaine and morphine on postamputation pain: a randomized double-blind, active placebo-controlled, crossover trial

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

The art of quality assessment of RCTs included in systematic reviews

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Physician interpretations and textbook definitions of blinding terminology in randomized controlled trials

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

The impact of blinding on the results of a randomized, placebo-controlled multiple sclerosis clinical trial

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Randomized Controlled Trial of Syn-Ergel and an Active Placebo in the Treatment of Heartburn of Pregnancy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Blinding and exclusions after allocation in randomised controlled trials: survey of published parallel group trials in obstetrics and gynaecology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

A checklist to evaluate a report of a nonpharmacological trial (CLEAR NPT) was developed using consensus

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Topical 4% amethocaine gel reduces the pain of subcutaneous measles-mumps-rubella vaccination

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Stimulant and relaxant drugs combined with stimulant and relaxant information: a study of active placebo

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Blinding was judged more difficult to achieve and maintain in nonpharmacologic than pharmacologic trials

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Splinting vs surgery in the treatment of carpal tunnel syndrome: a randomized controlled trial

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

In randomized controlled trials, should subjects in both placebo and drug groups be expected to guess that they are taking drug 50% of the time?

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

Blinding in randomised trials: hiding who got what.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1626553

The Landscape and Lexicon of Blinding in Randomized Trials

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/17076559

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dose dependence and time course of the immunologic response to administration of standardized cat allergen extract

1 reference

https://pubmed.ncbi.nlm.nih.gov/17076559

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Lessons learned from attempts to establish the blind in placebo-controlled trials of zinc for the common cold

1 reference

https://pubmed.ncbi.nlm.nih.gov/17076559

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PMED.0030425

0 references

PMC publication ID

1626553

0 references