Actinin alpha 2 (Q21096407)

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mammalian protein found in Homo sapiens
  • F-actin cross-linking protein
  • ACTN2
  • Alpha-actinin skeletal muscle isoform 2
  • alpha-actinin skeletal muscle
  • alpha-actinin-2
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Language Label Description Also known as
English
Actinin alpha 2
mammalian protein found in Homo sapiens
  • F-actin cross-linking protein
  • ACTN2
  • Alpha-actinin skeletal muscle isoform 2
  • alpha-actinin skeletal muscle
  • alpha-actinin-2

Statements

molecular function
protein binding
determination method
IPI
24 references
retrieved
8 April 2019
stated in
ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways
GOA
curator
UniProt
UniProt protein ID
P35609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
ZASP: a new Z-band alternatively spliced PDZ-motif protein
GOA
curator
UniProt
UniProt protein ID
P35609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.
GOA
curator
UniProt
UniProt protein ID
P35609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner
GOA
curator
UniProt
UniProt protein ID
P35609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin
GOA
curator
UniProt
UniProt protein ID
P35609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins
GOA
curator
UniProt
UniProt protein ID
P35609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Titin mutations as the molecular basis for dilated cardiomyopathy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha -actinin-2, is required for myoblast fusion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Alpha-actinin-2, a cytoskeletal protein, binds to angiogenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Decreased interactions of mutant muscle LIM protein (MLP) with N-RAP and alpha-actinin and their implication for hypertrophic cardiomyopathy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Comparative gene identification-94--a pivotal regulator of apoptosis
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
retrieved
8 April 2019
stated in
Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35609
determination method
IPI
cell component
biological process

Identifiers

 
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