Aldehyde dehydrogenase 3 family member A2 (Q21097156)

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mammalian protein found in Homo sapiens

aldehyde dehydrogenase 10
fatty aldehyde dehydrogenase
microsomal aldehyde dehydrogenase
ALDH3A2
aldehyde dehydrogenase family 3 member A2

Language	Label	Description	Also known as
English	Aldehyde dehydrogenase 3 family member A2	mammalian protein found in Homo sapiens	aldehyde dehydrogenase 10 fatty aldehyde dehydrogenase microsomal aldehyde dehydrogenase ALDH3A2 aldehyde dehydrogenase family 3 member A2

Statements

1 reference

13 November 2019

UniProt protein ID

Aldehyde/histidinol dehydrogenase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51648

Aldehyde dehydrogenase NAD(P)-dependent

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51648

Aldehyde dehydrogenase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51648

Aldehyde dehydrogenase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51648

Aldehyde dehydrogenase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aldehyde dehydrogenase, glutamic acid active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aldehyde dehydrogenase, cysteine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

long-chain-aldehyde dehydrogenase activity

determination method

1 reference

8 April 2019

A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

long-chain-alcohol oxidase activity

determination method

1 reference

8 April 2019

Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

medium-chain-aldehyde dehydrogenase activity

determination method

1 reference

8 April 2019

A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

aldehyde dehydrogenase (NAD+) activity

determination method

7 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51648&geneProductId=UniProtKB:P51648

determination method

10 September 2018

Identification of fatty aldehyde dehydrogenase in the breakdown of phytol to phytanic acid

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51648&geneProductId=UniProtKB:P51648

determination method

10 September 2018

Sjögren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51648&geneProductId=UniProtKB:P51648

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51648&geneProductId=UniProtKB:P51648

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51648&geneProductId=UniProtKB:P51648

determination method

10 September 2018

Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51648&geneProductId=UniProtKB:P51648

determination method

10 September 2018

Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51648&geneProductId=UniProtKB:P51648

determination method

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

protein binding

determination method

1 reference

8 April 2019

A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

3-chloroallyl aldehyde dehydrogenase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

aldehyde dehydrogenase (NAD+) activity

determination method

5 references

8 April 2019

Sjögren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

8 April 2019

Identification of fatty aldehyde dehydrogenase in the breakdown of phytol to phytanic acid

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

8 April 2019

Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

intracellular membrane-bounded organelle

determination method

1 reference

24 April 2018

Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51648&geneProductId=UniProtKB:P51648

determination method

determination method

1 reference

5 June 2018

Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51648&geneProductId=UniProtKB:P51648

determination method

peroxisomal membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

organelle membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

biological process

peripheral nervous system development

determination method

1 reference

8 April 2019

Sjögren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

sesquiterpenoid metabolic process

determination method

1 reference

5 June 2018

Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51648&geneProductId=UniProtKB:P51648

determination method

phytol metabolic process

determination method

1 reference

8 April 2019

Identification of fatty aldehyde dehydrogenase in the breakdown of phytol to phytanic acid

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

sphingolipid biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

cellular aldehyde metabolic process

determination method

3 references

8 April 2019

Sjögren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

8 April 2019

Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

central nervous system development

determination method

1 reference

8 April 2019

Sjögren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

epidermis development

determination method

1 reference

8 April 2019

Sjögren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

determination method

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51648&geneProductId=UniProtKB:P51648

determination method

fatty acid alpha-oxidation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

hexadecanal metabolic process

determination method

1 reference

8 April 2019

A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

lipid metabolism

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

fatty acid metabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51648

determination method

Aldehyde dehydrogenase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51648

Aldehyde dehydrogenase, glutamic acid active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51648

Aldehyde dehydrogenase, cysteine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51648

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000176643

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000176643

ENSP00000345774

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000345774

ENSP00000378942

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378942

ENSP00000461916

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000461916

ENSP00000463637

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463637

ENSP00000458397

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458397

ENSP00000458942

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458942

ENSP00000459977

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000459977

ENSP00000461235

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000461235

ENSP00000462933

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462933

ENSP00000462964

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462964

ENSP00000463128

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463128

ENSP00000463924

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463924

ENSP00000464153

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464153

ENSP00000464453

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464453

ENSP00000466814

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466814

ENSP00000486085

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486085

ENSP00000486283

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486283

ENSP00000487353

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487353

ENSP00000500092

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500092

ENSP00000500517

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500517

ENSP00000500740

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500740

ENSP00000500380

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500380

ENSP00000499877

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499877

ENSP00000500777

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500777

ENSP00000500516

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500516

ENSP00000500558

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500558

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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