BCL2 like 11 (Q21100273)

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mammalian protein found in Homo sapiens
  • BCL2L11
  • Bcl2-interacting mediator of cell death
  • bcl-2 interacting protein Bim
  • bcl-2 interacting mediator of cell death
  • bcl-2-related ovarian death agonist
  • BCL2-like 11 (apoptosis facilitator)
  • bcl-2-like protein 11
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Language Label Description Also known as
English
BCL2 like 11
mammalian protein found in Homo sapiens
  • BCL2L11
  • Bcl2-interacting mediator of cell death
  • bcl-2 interacting protein Bim
  • bcl-2 interacting mediator of cell death
  • bcl-2-related ovarian death agonist
  • BCL2-like 11 (apoptosis facilitator)
  • bcl-2-like protein 11

Statements

molecular function
protein binding
determination method
IPI
27 references
retrieved
8 April 2019
stated in
Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Structure homology and interaction redundancy for discovering virus-host protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
RACK1 and CIS mediate the degradation of BimEL in cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
High-throughput methods to detect dimerization of Bcl-2 family proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein Bax
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
BAX activation is initiated at a novel interaction site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
BAX-induced apoptosis can be initiated through a conformational selection mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
retrieved
8 April 2019
stated in
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
determination method
IPI
cell component
biological process

Identifiers

RefSeq protein ID
Ensembl protein ID
PDB structure ID
 
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