BRCA1/BRCA2-containing complex subunit 3 (Q21100456)

http://www.ebi.ac.uk/interpro/protein/P46736

MPN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

JAB1/MPN/MOV34 metalloenzyme domain family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

enzyme regulator activity

1 reference

8 April 2019

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

polyubiquitin modification-dependent protein binding

1 reference

27 February 2018

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

peptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

protein binding

6 references

8 April 2019

MERIT40 facilitates BRCA1 localization and DNA damage repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

Defining the human deubiquitinating enzyme interaction landscape

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

metallopeptidase activity

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

5 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

Lys63-specific deubiquitinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

thiol-dependent deubiquitinase

3 references

27 February 2018

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

thiol-dependent deubiquitinase

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

metallopeptidase activity

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

polyubiquitin modification-dependent protein binding

thiol-dependent deubiquitinase

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

cell component

spindle pole

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

nuclear ubiquitin ligase complex

1 reference

8 April 2019

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

ubiquitin ligase complex

1 reference

8 April 2019

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

BRCA1-A complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

6 references

27 February 2018

27 February 2018

MERIT40 facilitates BRCA1 localization and DNA damage repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

BRISC complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

3 references

27 February 2018

27 February 2018

A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

BRCA1-A complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

7 references

8 April 2019

8 April 2019

MERIT40 facilitates BRCA1 localization and DNA damage repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

BRISC complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

4 references

8 April 2019

8 April 2019

A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

response to ionizing radiation

biological process

3 references

8 April 2019

MERIT40 facilitates BRCA1 localization and DNA damage repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

positive regulation of DNA repair

3 references

8 April 2019

MERIT40 facilitates BRCA1 localization and DNA damage repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

cell division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

histone H2A K63-linked deubiquitination

double-strand break repair via nonhomologous end joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

response to X-ray

1 reference

8 April 2019

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

regulation of catalytic activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

double-strand break repair

3 references

27 February 2018

MERIT40 facilitates BRCA1 localization and DNA damage repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

protein deubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

protein K63-linked deubiquitination

A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

27 February 2018

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

27 February 2018

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46736&geneProductId=UniProtKB:P46736

mitotic G2 DNA damage checkpoint signaling

3 references

8 April 2019

MERIT40 facilitates BRCA1 localization and DNA damage repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

chromatin organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

1 reference

8 April 2019

DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

double-strand break repair

MERIT40 facilitates BRCA1 localization and DNA damage repair

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

protein K63-linked deubiquitination

A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

8 April 2019

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

histone H2A K63-linked deubiquitination

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46736

JAB1/MPN/MOV34 metalloenzyme domain

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46736

MPN domain

1 reference

InterPro Release 71.0