Rho associated coiled-coil containing protein kinase 1 (Q21100658)

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mammalian protein found in Homo sapiens

• ROCK-I
• ROCK1
• p160 ROCK-1
• Rho-associated, coiled-coil-containing protein kinase I
• p160ROCK
• Rho-associated, coiled-coil-containing protein kinase 1
• rho-associated protein kinase 1
• renal carcinoma antigen NY-REN-35

edit

Language	Label	Description	Also known as
English	Rho associated coiled-coil containing protein kinase 1	mammalian protein found in Homo sapiens	ROCK-I ROCK1 p160 ROCK-1 Rho-associated, coiled-coil-containing protein kinase I p160ROCK Rho-associated, coiled-coil-containing protein kinase 1 rho-associated protein kinase 1 renal carcinoma antigen NY-REN-35

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q13464

part of

Rho-associated protein kinase 1/2

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13464

Protein kinase-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13464

PH-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13464

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rho binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rho-associated protein kinase 1, HR1, protein family

1 reference

based on heuristic

inferred from protein domain or family

AGC-kinase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

Protein ROCK1 PDB 1s1c.png
752 × 521; 204 KB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q13464

encoded by

ROCK1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q13464

molecular function

transferase activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

protein kinase activity

determination method

TAS

IEA

3 references

retrieved

9 May 2019

stated in

Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

9 May 2019

stated in

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

nucleotide binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

metal ion binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

kinase activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

protein serine/threonine kinase activity

determination method

IDA

IEA

TAS

9 references

retrieved

31 October 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

31 October 2017

stated in

Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

31 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

31 October 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

31 October 2017

stated in

The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

31 October 2017

stated in

Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

31 October 2017

stated in

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

31 October 2017

stated in

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

31 October 2017

stated in

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

IDA

protein binding

determination method

IPI

9 references

retrieved

9 May 2019

stated in

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IPI

retrieved

9 May 2019

stated in

Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IPI

retrieved

9 May 2019

stated in

Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IPI

retrieved

9 May 2019

stated in

Arachidonic acid stimulates formation of a novel complex containing nucleolin and RhoA

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IPI

retrieved

9 May 2019

stated in

MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IPI

retrieved

9 May 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IPI

retrieved

9 May 2019

stated in

FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IPI

retrieved

9 May 2019

stated in

Structural insights into the interaction of ROCKI with the switch regions of RhoA

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IPI

retrieved

9 May 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IPI

ATP binding

determination method

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

protein serine/threonine kinase activity

determination method

IDA

IEA

NAS

TAS

9 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

8 April 2019

stated in

Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

8 April 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

NAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

8 April 2019

stated in

Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

8 April 2019

stated in

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

8 April 2019

stated in

The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

8 April 2019

stated in

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

tau protein binding

determination method

NAS

1 reference

retrieved

9 May 2019

stated in

Roles of tau protein in health and disease

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

NAS

tau-protein kinase activity

determination method

NAS

1 reference

retrieved

9 May 2019

stated in

Roles of tau protein in health and disease

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

NAS

Rho-dependent protein serine/threonine kinase activity

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

protein serine/threonine kinase activity

determination method

IBA

IDA

IEA

NAS

TAS

10 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

9 May 2019

stated in

Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

9 May 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

NAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

9 May 2019

stated in

Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

9 May 2019

stated in

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

9 May 2019

stated in

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

Rho-dependent protein serine/threonine kinase activity

determination method

IBA

IDA

2 references

retrieved

9 May 2019

stated in

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

cell component

cytoplasm

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

cytosol

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

Golgi apparatus

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

cell projection

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

membrane

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

ruffle

determination method

ISS

IEA

3 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

Golgi membrane

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

plasma membrane

determination method

ISS

IEA

3 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

bleb

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

centriole

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

cytoskeleton

determination method

ISS

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

lamellipodium

determination method

ISS

IEA

3 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

extracellular region

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

secretory granule lumen

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

cytoplasmic stress granule

determination method

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

amyloid-beta complex

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

cytoplasm

determination method

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

cytoskeleton

determination method

IBA

IEA

ISS

4 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

cytoplasmic stress granule

determination method

IBA

IEA

ISS

3 references

retrieved

9 May 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

biological process

negative regulation of neuron apoptotic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

leukocyte cell-cell adhesion

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

smooth muscle contraction

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

Rocks: multifunctional kinases in cell behaviour

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

myoblast migration

determination method

ISS

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

intracellular signal transduction

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

regulation of actin cytoskeleton organization

determination method

IDA

TAS

2 references

retrieved

9 May 2019

stated in

Rocks: multifunctional kinases in cell behaviour

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

9 May 2019

stated in

Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

phosphorylation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

ephrin receptor signaling pathway

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

bleb assembly

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

negative regulation of protein binding

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

regulation of actin filament-based process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

regulation of stress fiber assembly

determination method

TAS

IEA

2 references

retrieved

8 April 2019

stated in

Rocks: multifunctional kinases in cell behaviour

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

regulation of cell motility

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

Rocks: multifunctional kinases in cell behaviour

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

protein phosphorylation

determination method

IEA

TAS

2 references

retrieved

9 May 2019

stated in

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

negative regulation of bicellular tight junction assembly

determination method

IGI

1 reference

retrieved

9 May 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

vascular endothelial growth factor receptor signaling pathway

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

regulation of cell adhesion

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

Rocks: multifunctional kinases in cell behaviour

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

Rho protein signal transduction

determination method

IEA

TAS

2 references

retrieved

31 October 2017

stated in

Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

31 October 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

IEA

membrane to membrane docking

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

leukocyte tethering or rolling

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

regulation of focal adhesion assembly

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

Rocks: multifunctional kinases in cell behaviour

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

negative regulation of angiogenesis

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

regulation of keratinocyte differentiation

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

positive regulation of focal adhesion assembly

determination method

ISS

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

negative regulation of myosin-light-chain-phosphatase activity

determination method

IGI

IMP

2 references

retrieved

9 May 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

retrieved

9 May 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

I-kappaB kinase/NF-kappaB signaling

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

regulation of establishment of cell polarity

determination method

TAS

IEA

2 references

retrieved

8 April 2019

stated in

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

cortical actin cytoskeleton organization

determination method

IGI

IMP

2 references

retrieved

8 April 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

retrieved

8 April 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

apical constriction

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

regulation of establishment of endothelial barrier

determination method

IGI

IMP

2 references

retrieved

9 May 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

retrieved

9 May 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

actin cytoskeleton organization

determination method

TAS

IEA

3 references

retrieved

9 May 2019

stated in

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

leukocyte migration

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

signal transduction

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

regulation of cytoskeleton organization

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

apoptotic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

neutrophil degranulation

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

execution phase of apoptosis

determination method

TAS

1 reference

retrieved

31 October 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464

determination method

TAS

protein localization to plasma membrane

determination method

IGI

IMP

2 references

retrieved

9 May 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

retrieved

9 May 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

G protein-coupled receptor signaling pathway

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

aortic valve morphogenesis

determination method

ISS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

Rho protein signal transduction

determination method

IEA

IGI

TAS

3 references

retrieved

8 April 2019

stated in

Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

8 April 2019

stated in

Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

regulation of autophagy

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

positive regulation of autophagy

determination method

IGI

1 reference

retrieved

9 May 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

positive regulation of cardiac muscle hypertrophy

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

positive regulation of gene expression

determination method

IMP

ISS

3 references

retrieved

9 May 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

retrieved

9 May 2019

stated in

Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

peptidyl-serine phosphorylation

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IDA

neuron projection development

determination method

IGI

1 reference

retrieved

9 May 2019

stated in

Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

positive regulation of MAPK cascade

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

regulation of neuron differentiation

determination method

IGI

1 reference

retrieved

9 May 2019

stated in

Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

negative regulation of membrane protein ectodomain proteolysis

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

negative regulation of biomineral tissue development

determination method

ISS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

response to transforming growth factor beta

determination method

IEA

ISS

2 references

retrieved

9 May 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

regulation of angiotensin-activated signaling pathway

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

neuron projection arborization

determination method

IGI

1 reference

retrieved

9 May 2019

stated in

Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

positive regulation of amyloid-beta clearance

determination method

IGI

1 reference

retrieved

9 May 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

regulation of synaptic vesicle endocytosis

determination method

IGI

1 reference

retrieved

9 May 2019

stated in

Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

regulation of amyloid-beta formation

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

negative regulation of amyloid-beta formation

determination method

IMP

2 references

retrieved

9 May 2019

stated in

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

retrieved

9 May 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

negative regulation of amyloid precursor protein catabolic process

determination method

IMP

2 references

retrieved

9 May 2019

stated in

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

retrieved

9 May 2019

stated in

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

positive regulation of connective tissue replacement

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

response to angiotensin

determination method

IEA

ISS

2 references

retrieved

9 May 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

mRNA destabilization

determination method

IEA

ISS

2 references

retrieved

9 May 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

blood vessel diameter maintenance

determination method

IEA

ISS

2 references

retrieved

9 May 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

mitotic cytokinesis

determination method

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

Rho protein signal transduction

determination method

IBA

IEA

IGI

TAS

4 references

retrieved

9 May 2019

stated in

Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

retrieved

9 May 2019

stated in

Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

peptidyl-threonine phosphorylation

determination method

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

cortical actin cytoskeleton organization

determination method

IBA

IGI

IMP

3 references

retrieved

9 May 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IMP

retrieved

9 May 2019

stated in

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IGI

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

actomyosin structure organization

determination method

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

embryonic morphogenesis

determination method

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

regulation of stress fiber assembly

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

Rocks: multifunctional kinases in cell behaviour

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

regulation of cell junction assembly

determination method

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

IBA

regulation of establishment of cell polarity

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

GOA

curator

UniProt

UniProt protein ID

Q13464

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464

determination method

TAS

physically interacts with

fasudil

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5181

language of work or name

English

retrieved

17 August 2016

Y-27632

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5290

language of work or name

English

retrieved

17 August 2016

ripasudil

object has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL3426621

SAR407899

object has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL1667969

verosudil

object has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL3545065

has part(s)

serine/threonine-protein kinase, active site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13464

pleckstrin homology domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13464

protein kinase domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13464

protein kinase, ATP binding site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13464

Rho binding domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13464

AGC-kinase, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13464

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13464

Rho-associated protein kinase 1, HR1

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13464

Identifiers

RefSeq protein ID

NP_005397

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6093

UniProt protein ID

Q13464

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q13464

Ensembl protein ID

ENSP00000382697

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000382697

ENSP00000462004

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000462004

ENSP00000489185

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000489185

Freebase ID

/m/03csqqb

0 references

Microsoft Academic ID

133717845

0 references

OpenAlex ID

C133717845

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1S1C

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

2ESM

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

2ETK

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

2ETR

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

2V55

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

3D9V

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

3NCZ

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

3NDM

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

3O0Z

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

3TV7

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

3TWJ

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

3V8S

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

4L2W

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

4W7P

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

4YVC

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

4YVE

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

5BML

1 reference

stated in

UniProt

UniProt protein ID

Q13464

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(4 entries)

edit

• dewiki Rho-Kinase 1
• enwiki ROCK1
• fawiki ROCK1
• ukwiki ROCK1

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21100658&oldid=2022914265"