Cullin 5 (Q21101987)

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mammalian protein found in Homo sapiens

vasopressin-activated calcium-mobilizing receptor 1
Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1)
CUL5
Vasopressin-activated calcium-mobilizing receptor-1
VACM-1
cullin-5

Language	Label	Description	Also known as
English	Cullin 5	mammalian protein found in Homo sapiens	vasopressin-activated calcium-mobilizing receptor 1 Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1) CUL5 Vasopressin-activated calcium-mobilizing receptor-1 VACM-1 cullin-5

Statements

1 reference

13 November 2019

UniProt protein ID

winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q93034

Cullin homology domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q93034

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q93034

Cullin repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q93034

Cullin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin protein, neddylation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method or standard

15 references

1 January 2018

Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

Global landscape of HIV-human protein complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

ubiquitin protein ligase activity

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

calcium channel activity

determination method or standard

1 reference

1 January 2018

Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

ubiquitin-protein transferase activity

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

signaling receptor activity

determination method or standard

1 reference

1 January 2018

Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

ubiquitin protein ligase binding

determination method or standard

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

cullin-RING ubiquitin ligase complex

determination method or standard

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q93034&geneProductId=UniProtKB:Q93034

determination method or standard

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

Cul5-RING ubiquitin ligase complex

determination method or standard

Cul4-RING E3 ubiquitin ligase complex

determination method or standard

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q93034&geneProductId=UniProtKB:Q93034

determination method or standard

Cul5-RING ubiquitin ligase complex

determination method or standard

3 references

1 January 2018

ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

SCF ubiquitin ligase complex

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

biological process

intrinsic apoptotic signaling pathway

determination method or standard

1 reference

1 January 2018

Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

cell population proliferation

determination method or standard

1 reference

1 January 2018

Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

ubiquitin-dependent protein catabolic process

determination method or standard

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q93034&geneProductId=UniProtKB:Q93034

determination method or standard

negative regulation of cell population proliferation

determination method or standard

1 reference

1 January 2018

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

protein ubiquitination

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

ERBB2 signaling pathway

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

calcium ion transmembrane transport

determination method or standard

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q93034&geneProductId=UniProtKB:Q93034

determination method or standard

post-translational protein modification

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

G1/S transition of mitotic cell cycle

determination method or standard

1 reference

1 January 2018

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93034

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000376808

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000376808

ENSP00000435376

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435376

ENSP00000431221

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000431221

ENSP00000436494

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436494

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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