Rho guanine nucleotide exchange factor 12 (Q21102005)

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mammalian protein found in Homo sapiens

rho guanine nucleotide exchange factor 12
Rho guanine nucleotide exchange factor (GEF) 12
leukemia-associated rho guanine nucleotide exchange factor
ARHGEF12
leukemia-associated RhoGEF

Language	Label	Description	Also known as
English	Rho guanine nucleotide exchange factor 12	mammalian protein found in Homo sapiens	rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor (GEF) 12 leukemia-associated rho guanine nucleotide exchange factor ARHGEF12 leukemia-associated RhoGEF

Statements

1 reference

13 November 2019

UniProt protein ID

Dbl homology (DH) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZN5

RGS domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZN5

PDZ superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZN5

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZN5

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Regulator of G protein signalling-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

LARG, RGS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

ARHGEF12, PH domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PDZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Dbl homology (DH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Guanine-nucleotide dissociation stimulator, CDC24, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

5 references

8 April 2019

HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

8 April 2019

Inter-domain motions of the N-domain of the KdpFABC complex, a P-type ATPase, are not driven by ATP-induced conformational changes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

8 April 2019

Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

8 April 2019

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

8 April 2019

A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

G protein-coupled receptor binding

determination method

1 reference

31 October 2017

Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZN5&geneProductId=UniProtKB:Q9NZN5

determination method

guanyl-nucleotide exchange factor activity

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

8 April 2019

Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

extracellular exosome

determination method

1 reference

31 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZN5&geneProductId=UniProtKB:Q9NZN5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

biological process

positive regulation of GTPase activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

regulation of Rho protein signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

intracellular signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

regulation of small GTPase mediated signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

regulation of molecular function

determination method

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZN5&geneProductId=UniProtKB:Q9NZN5

determination method

G protein-coupled receptor signaling pathway

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

8 April 2019

Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

Rho protein signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZN5

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZN5

Dbl homology (DH) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZN5

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZN5

Regulator of G protein signalling-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZN5

Guanine-nucleotide dissociation stimulator, CDC24, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZN5

ARHGEF12, PH domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZN5

LARG, RGS domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZN5

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000349056

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000349056

ENSP00000380942

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380942

ENSP00000432984

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432984

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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