Ariadne RBR E3 ubiquitin protein ligase 1 (Q21102006)

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mammalian protein found in Homo sapiens

E3 ubiquitin-protein ligase ARIH1
monocyte protein 6
ARI-1
MOP-6
ubcM4-interacting protein
H7-AP2
ARIH1
HHARI
protein ariadne-1 homolog
ubiquitin-conjugating enzyme E2-binding protein 1
ariadne, Drosophila, homolog of
ubcH7-binding protein
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1

Language	Label	Description	Also known as
English	Ariadne RBR E3 ubiquitin protein ligase 1	mammalian protein found in Homo sapiens	E3 ubiquitin-protein ligase ARIH1 monocyte protein 6 ARI-1 MOP-6 ubcM4-interacting protein H7-AP2 ARIH1 HHARI protein ariadne-1 homolog ubiquitin-conjugating enzyme E2-binding protein 1 ariadne, Drosophila, homolog of ubcH7-binding protein ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1

Statements

1 reference

13 November 2019

UniProt protein ID

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4X5

E3 ubiquitin ligase RBR family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4X5

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

IBR domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ubiquitin-like protein transferase activity

determination method

1 reference

8 April 2019

The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

protein binding

determination method

5 references

8 April 2019

The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

ubiquitin protein ligase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

ubiquitin protein ligase binding

determination method

ubiquitin-protein transferase activity

determination method

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

ubiquitin conjugating enzyme binding

determination method

3 references

27 February 2018

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4X5&geneProductId=UniProtKB:Q9Y4X5

determination method

27 February 2018

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4X5&geneProductId=UniProtKB:Q9Y4X5

determination method

27 February 2018

Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4X5&geneProductId=UniProtKB:Q9Y4X5

determination method

zinc ion binding

determination method

ubiquitin conjugating enzyme binding

determination method

4 references

8 April 2019

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

determination method

3 references

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4X5&geneProductId=UniProtKB:Q9Y4X5

determination method

27 February 2018

Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4X5&geneProductId=UniProtKB:Q9Y4X5

determination method

27 February 2018

Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4X5&geneProductId=UniProtKB:Q9Y4X5

determination method

ubiquitin ligase complex

determination method

1 reference

27 February 2018

The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4X5&geneProductId=UniProtKB:Q9Y4X5

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

determination method

1 reference

8 April 2019

Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

Cul4A-RING E3 ubiquitin ligase complex

determination method

1 reference

8 April 2019

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

determination method

1 reference

8 April 2019

The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

biological process

protein polyubiquitination

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

protein ubiquitination

determination method

8 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

ubiquitin-dependent protein catabolic process

determination method

3 references

8 April 2019

The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4X5

determination method

Zinc finger, RING-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4X5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4X5

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000369217

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000369217

ENSP00000454774

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000454774

ENSP00000456746

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000456746

ENSP00000457767

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000457767

ENSP00000477687

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477687

PDB structure ID

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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