Troponin T2, cardiac type (Q21104681)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

Cardiac muscle troponin T
cTnT
cardiomyopathy, dilated 1D (autosomal dominant)
cardiomyopathy, hypertrophic 2
troponin T type 2 (cardiac)
troponin T, cardiac muscle
truncated cardiac troponin T
TNNT2

Language	Label	Description	Also known as
English	Troponin T2, cardiac type	mammalian protein found in Homo sapiens	Cardiac muscle troponin T cTnT cardiomyopathy, dilated 1D (autosomal dominant) cardiomyopathy, hypertrophic 2 troponin T type 2 (cardiac) troponin T, cardiac muscle truncated cardiac troponin T TNNT2

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P45379

Troponin domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P45379

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein-macromolecule adaptor activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

ATPase activity

determination method

protein binding

determination method

1 reference

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

determination method

1 reference

8 April 2019

Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

tropomyosin binding

determination method

1 reference

24 April 2018

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P45379&geneProductId=UniProtKB:P45379

determination method

troponin C binding

determination method

calcium ion binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

tropomyosin binding

determination method

troponin C binding

determination method

3 references

8 April 2019

Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

calcium-dependent ATPase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

troponin I binding

determination method

3 references

8 April 2019

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

troponin complex

determination method

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P45379&geneProductId=UniProtKB:P45379

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P45379&geneProductId=UniProtKB:P45379

determination method

24 April 2018

Ca2+, pH and the regulation of cardiac myofilament force and ATPase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P45379&geneProductId=UniProtKB:P45379

determination method

24 April 2018

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P45379&geneProductId=UniProtKB:P45379

determination method

24 April 2018

Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P45379&geneProductId=UniProtKB:P45379

determination method

determination method

1 reference

8 April 2019

Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

striated muscle thin filament

determination method

1 reference

8 April 2019

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

cardiac myofibril

determination method

1 reference

8 April 2019

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

cardiac Troponin complex

determination method

1 reference

8 April 2019

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

troponin complex

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

biological process

muscle contraction

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P45379&geneProductId=UniProtKB:P45379

determination method

regulation of heart contraction

determination method

1 reference

8 April 2019

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

positive regulation of ATP-dependent activity

determination method

2 references

8 April 2019

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

negative regulation of ATP-dependent activity

determination method

1 reference

8 April 2019

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

response to calcium ion

determination method

ventricular cardiac muscle tissue morphogenesis

determination method

1 reference

8 April 2019

Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

actin crosslink formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

muscle filament sliding

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

regulation of muscle filament sliding speed

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

protein heterooligomerization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

skeletal muscle contraction

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

sarcomere organization

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

response to calcium ion

determination method

1 reference

8 April 2019

Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

cardiac muscle contraction

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45379

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000236918

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000236918

ENSP00000353535

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353535

ENSP00000356287

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356287

ENSP00000356289

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356289

ENSP00000356291

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356291

ENSP00000422031

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422031

ENSP00000356284

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356284

ENSP00000356286

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356286

ENSP00000387874

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000387874

ENSP00000395163

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000395163

ENSP00000402238

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000402238

ENSP00000404134

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000404134

ENSP00000408731

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408731

ENSP00000414036

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000414036

ENSP00000499418

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499418

ENSP00000499667

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499667

ENSP00000499741

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499741

ENSP00000499590

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499590

ENSP00000499796

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499796

ENSP00000499593

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499593

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21104681&oldid=2022922303"