Phosphoinositide-3-kinase regulatory subunit 3 (Q21104857)

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mammalian protein found in Homo sapiens

PIK3R3
phosphatidylinositol 3-kinase regulatory subunit gamma
phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
ptdIns-3-kinase regulatory subunit p55-gamma
PI3K regulatory subunit gamma
PI3-kinase regulatory subunit gamma
PI3-kinase subunit p55-gamma
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)
p55PIK

Language	Label	Description	Also known as
English	Phosphoinositide-3-kinase regulatory subunit 3	mammalian protein found in Homo sapiens	PIK3R3 phosphatidylinositol 3-kinase regulatory subunit gamma phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma phosphoinositide-3-kinase, regulatory subunit 3 (gamma) ptdIns-3-kinase regulatory subunit p55-gamma PI3K regulatory subunit gamma PI3-kinase regulatory subunit gamma PI3-kinase subunit p55-gamma phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) p55PIK

Statements

1 reference

13 November 2019

UniProt protein ID

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92569

PI3K p85 subunit, inter-SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PI3K p85 subunit, C-terminal SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PI3K p85 subunit, N-terminal SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

phosphatidylinositol 3-kinase regulator activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

protein binding

determination method

12 references

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

8 April 2019

A quantitative protein interaction network for the ErbB receptors using protein microarrays

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

8 April 2019

Phospho-tyrosine dependent protein-protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

8 April 2019

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

8 April 2019

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

8 April 2019

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

8 April 2019

Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

8 April 2019

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

8 April 2019

Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

8 April 2019

Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

8 April 2019

Charting the molecular network of the drug target Bcr-Abl

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

1-phosphatidylinositol-3-kinase activity

determination method

1 reference

8 April 2019

Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

phosphotyrosine residue binding

determination method

1 reference

8 April 2019

Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

1-phosphatidylinositol-3-kinase regulator activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

biological process

regulation of phosphatidylinositol 3-kinase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

phosphatidylinositol-3-phosphate biosynthetic process

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

insulin receptor signaling pathway

determination method

3 references

24 April 2018

Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92569&geneProductId=UniProtKB:Q92569

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92569&geneProductId=UniProtKB:Q92569

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92569&geneProductId=UniProtKB:Q92569

determination method

positive regulation of protein phosphorylation

determination method

1 reference

8 April 2019

Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

cell migration involved in sprouting angiogenesis

determination method

1 reference

8 April 2019

Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

insulin receptor signaling pathway

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

protein kinase B signaling

determination method

1 reference

8 April 2019

Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

positive regulation of cell migration

determination method

1 reference

8 April 2019

MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

phosphatidylinositol phosphate biosynthetic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

phosphatidylinositol biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92569

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000262741

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000262741

ENSP00000361075

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000361075

ENSP00000391431

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391431

ENSP00000412546

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412546

ENSP00000416647

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000416647

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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