Protein kinase cAMP-dependent type II regulatory subunit alpha (Q21105026)

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mammalian protein found in Homo sapiens

cAMP-dependent protein kinase regulatory subunit RII alpha
PRKAR2A
protein kinase A, RII-alpha subunit
protein kinase, cAMP-dependent, regulatory subunit type II alpha
cAMP-dependent protein kinase type II-alpha regulatory subunit

Language	Label	Description	Also known as
English	Protein kinase cAMP-dependent type II regulatory subunit alpha	mammalian protein found in Homo sapiens	cAMP-dependent protein kinase regulatory subunit RII alpha PRKAR2A protein kinase A, RII-alpha subunit protein kinase, cAMP-dependent, regulatory subunit type II alpha cAMP-dependent protein kinase type II-alpha regulatory subunit

Statements

1 reference

13 November 2019

UniProt protein ID

RmlC-like jelly roll fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13861

Cyclic nucleotide-binding-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13861

cAMP-dependent protein kinase regulatory subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13861

cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cyclic nucleotide-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cyclic nucleotide-binding, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

protein kinase A catalytic subunit binding

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

protein binding

determination method

13 references

8 April 2019

Characterization of an A-kinase anchoring protein in human ciliary axonemes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

Differential PKA activation and AKAP association determines cell fate in cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

Binding of PKA-RIIalpha to the Adenovirus E1A12S oncoprotein correlates with its nuclear translocation and an increase in PKA-dependent promoter activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

cAMP-dependent protein kinase regulator activity

determination method

3 references

8 April 2019

Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RII alpha of cAMP-dependent protein kinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

cAMP-dependent protein kinase inhibitor activity

determination method

1 reference

8 April 2019

The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

Control of PKA stability and signalling by the RING ligase praja2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

protein domain specific binding

determination method

1 reference

8 April 2019

A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

3',5'-cyclic-GMP phosphodiesterase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

determination method

3 references

8 April 2019

Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

Control of PKA stability and signalling by the RING ligase praja2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13861&geneProductId=UniProtKB:P13861

determination method

determination method

1 reference

8 April 2019

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

determination method

3 references

17 October 2017

Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13861&geneProductId=UniProtKB:P13861

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13861&geneProductId=UniProtKB:P13861

determination method

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13861&geneProductId=UniProtKB:P13861

determination method

determination method

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13861&geneProductId=UniProtKB:P13861

determination method

plasma membrane raft

determination method

1 reference

8 April 2019

Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

plasma membrane

determination method

3 references

8 April 2019

Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

Control of PKA stability and signalling by the RING ligase praja2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

nucleotide-activated protein kinase complex

determination method

1 reference

8 April 2019

The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

extracellular exosome

determination method

3 references

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13861&geneProductId=UniProtKB:P13861

determination method

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13861&geneProductId=UniProtKB:P13861

determination method

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13861&geneProductId=UniProtKB:P13861

determination method

determination method

1 reference

8 April 2019

Characterization of an A-kinase anchoring protein in human ciliary axonemes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

determination method

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

determination method

3 references

8 April 2019

Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

protein-containing complex

determination method

1 reference

8 April 2019

A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

extracellular exosome

determination method

3 references

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

biological process

regulation of protein phosphorylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

activation of protein kinase A activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

intracellular signal transduction

determination method

1 reference

8 April 2019

Human testis cDNA for the regulatory subunit RII alpha of cAMP-dependent protein kinase encodes an alternate amino-terminal region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

cellular response to glucagon stimulus

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

blood coagulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

negative regulation of cAMP-dependent protein kinase activity

determination method

1 reference

8 April 2019

The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

renal water homeostasis

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

cGMP-mediated signaling

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13861

determination method

physically interacts with

determination method

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Cyclic nucleotide-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13861

Cyclic nucleotide-binding, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13861

cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13861

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000265563

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000265563

ENSP00000296446

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000296446

ENSP00000394041

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000394041

ENSP00000400840

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000400840

ENSP00000409239

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409239

ENSP00000411432

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411432

ENSP00000416438

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000416438

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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