aldo-keto reductase family 1 member C3 (Q21105060)

NADP-dependent oxidoreductase domain superfamily

1 reference

NADP-dependent oxidoreductase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aldo/keto reductase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

delta4-3-oxosteroid 5beta-reductase activity

1 reference

8 April 2019

A novel polymorphism in the 17beta-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian men

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

prostaglandin-F synthase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

alditol:NADP+ 1-oxidoreductase activity

1 reference

26 September 2017

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42330&geneProductId=UniProtKB:P42330

retinal dehydrogenase activity

1 reference

8 April 2019

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

geranylgeranyl reductase activity

1 reference

8 April 2019

Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

indanol dehydrogenase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

aldo-keto reductase (NADP) activity

1 reference

8 April 2019

Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

dihydrotestosterone 17-beta-dehydrogenase activity

1 reference

8 April 2019

A novel polymorphism in the 17beta-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian men

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

phenanthrene 9,10-monooxygenase activity

1 reference

8 April 2019

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects

ketoreductase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

testosterone dehydrogenase (NAD+) activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

NAD-retinol dehydrogenase activity

1 reference

8 April 2019

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

testosterone 17-beta-dehydrogenase (NADP+) activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

androsterone dehydrogenase activity

1 reference

26 September 2017

A novel polymorphism in the 17beta-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian men

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42330&geneProductId=UniProtKB:P42330

15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

1 reference

8 April 2019

Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

ketosteroid monooxygenase activity

1 reference

26 September 2017

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42330&geneProductId=UniProtKB:P42330

NADP-retinol dehydrogenase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

prostaglandin H2 endoperoxidase reductase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

alcohol dehydrogenase (NADP+) activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

steroid dehydrogenase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

oxidoreductase activity

androsterone dehydrogenase activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

8 April 2019

Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

8 April 2019

Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

8 April 2019

Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

8 April 2019

Developmental evaluation of aldo-keto reductase 1C3 expression in the cryptorchid testis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42330&geneProductId=UniProtKB:P42330

intracellular anatomical structure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

cellular response to calcium ion

HDA

biological process

1 reference

8 April 2019

Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

negative regulation of retinoic acid biosynthetic process

1 reference

8 April 2019

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

prostaglandin metabolic process

2 references

26 September 2017

Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42330&geneProductId=UniProtKB:P42330

26 September 2017

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42330&geneProductId=UniProtKB:P42330

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

cellular response to jasmonic acid stimulus

1 reference

8 April 2019

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

steroid metabolic process

1 reference

26 September 2017

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42330&geneProductId=UniProtKB:P42330

positive regulation of protein kinase B signaling

1 reference

8 April 2019

AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

Developmental evaluation of aldo-keto reductase 1C3 expression in the cryptorchid testis

male gonad development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

positive regulation of cell death

1 reference

8 April 2019

Cadmium-induced up-regulation of aldo-keto reductase 1C3 expression in human nasal septum carcinoma RPMI-2650 cells: Involvement of reactive oxygen species and phosphatidylinositol 3-kinase/Akt

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

daunorubicin metabolic process

1 reference

26 September 2017

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42330&geneProductId=UniProtKB:P42330

doxorubicin metabolic process

IMP

1 reference

26 September 2017

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42330&geneProductId=UniProtKB:P42330

1 reference

8 April 2019

AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

regulation of retinoic acid receptor signaling pathway

1 reference

8 April 2019

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

progesterone metabolic process

1 reference

26 September 2017

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42330&geneProductId=UniProtKB:P42330

cellular response to starvation

1 reference

8 April 2019

Regulation of human aldoketoreductase 1C3 (AKR1C3) gene expression in the adipose tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

regulation of testosterone biosynthetic process

1 reference

8 April 2019

Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

cellular response to cadmium ion

IMP

1 reference

8 April 2019

Cadmium-induced up-regulation of aldo-keto reductase 1C3 expression in human nasal septum carcinoma RPMI-2650 cells: Involvement of reactive oxygen species and phosphatidylinositol 3-kinase/Akt

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

cellular response to corticosteroid stimulus

1 reference

8 April 2019

Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

cyclooxygenase pathway

1 reference

8 April 2019

keratinocyte differentiation

1 reference

8 April 2019

Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

retinal metabolic process

1 reference

8 April 2019

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

retinoid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

cellular response to reactive oxygen species

1 reference

8 April 2019

Cadmium-induced up-regulation of aldo-keto reductase 1C3 expression in human nasal septum carcinoma RPMI-2650 cells: Involvement of reactive oxygen species and phosphatidylinositol 3-kinase/Akt

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

farnesol catabolic process

1 reference

8 April 2019

Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

positive regulation of endothelial cell apoptotic process

1 reference

8 April 2019

Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

positive regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

cellular response to prostaglandin D stimulus

1 reference

8 April 2019

AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

positive regulation of cell population proliferation

3 references

8 April 2019

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

8 April 2019

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

8 April 2019

AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

1 reference

8 April 2019

Localization of cyclooxygenases-1 and -2, and prostaglandin F synthase in human kidney and renal cell carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

testosterone biosynthetic process

NAS

1 reference

8 April 2019

A novel polymorphism in the 17beta-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian men

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

cellular response to prostaglandin stimulus

IMP

1 reference

8 April 2019

Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

retinol metabolic process

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

prostaglandin metabolic process

3 references

8 April 2019

Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

8 April 2019

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

steroid metabolic process

macromolecule metabolic process

1 reference

8 April 2019

Regulation of human aldoketoreductase 1C3 (AKR1C3) gene expression in the adipose tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42330

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8769

http://www.uniprot.org/uniprot/P42330.txt?version=173

English

retrieved

17 August 2016

EC enzyme number

1.3.1.20

1 reference

4 January 2016

has part(s)

Aldo/keto reductase, conserved site

1 reference

NADP-dependent oxidoreductase domain

1 reference

D08.811.682.047.150.700.156.875

Identifiers

MeSH descriptor ID

D000074425

subject named as

Aldo-Keto Reductase Family 1 Member C3

0 references

MeSH tree code

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D08.811.682.047.436.375.140

0 references

D08.811.682.047.820.284.937

0 references

D08.811.682.047.820.375.500

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference