aldo-keto reductase family 1 member C2 (Q21105063)

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mammalian protein found in Homo sapiens

1.3.1.20
Type III 3-alpha-hydroxysteroid dehydrogenase
Dihydrodiol dehydrogenase/bile acid-binding protein
DD-2
DD/BABP
DD2
3-alpha-HSD3
chlordecone reductase homolog HAKRD
Dihydrodiol dehydrogenase 2
testicular 17,20-desmolase deficiency
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
1.1.1.357
type II dihydrodiol dehydrogenase
AKR1C2
dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III
pseudo-chlordecone reductase

Language	Label	Description	Also known as
English	aldo-keto reductase family 1 member C2	mammalian protein found in Homo sapiens	1.3.1.20 Type III 3-alpha-hydroxysteroid dehydrogenase Dihydrodiol dehydrogenase/bile acid-binding protein DD-2 DD/BABP DD2 3-alpha-HSD3 chlordecone reductase homolog HAKRD Dihydrodiol dehydrogenase 2 testicular 17,20-desmolase deficiency trans-1,2-dihydrobenzene-1,2-diol dehydrogenase 1.1.1.357 type II dihydrodiol dehydrogenase AKR1C2 dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III pseudo-chlordecone reductase

Statements

1 reference

13 November 2019

UniProt protein ID

aldo/keto reductase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52895

NADP-dependent oxidoreductase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52895

NADP-dependent oxidoreductase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aldo/keto reductase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

alditol:NADP+ 1-oxidoreductase activity

determination method

1 reference

27 March 2018

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52895&geneProductId=UniProtKB:P52895

determination method

phenanthrene 9,10-monooxygenase activity

determination method

1 reference

8 April 2019

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

determination method

1 reference

8 April 2019

Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

bile acid binding

determination method

1 reference

8 April 2019

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

carboxylic acid binding

determination method

1 reference

8 April 2019

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

ketosteroid monooxygenase activity

determination method

1 reference

27 March 2018

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52895&geneProductId=UniProtKB:P52895

determination method

alcohol dehydrogenase (NADP+) activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

steroid dehydrogenase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

oxidoreductase activity

determination method

biological process

prostaglandin metabolic process

determination method

1 reference

8 April 2019

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

cellular response to jasmonic acid stimulus

determination method

1 reference

8 April 2019

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

epithelial cell differentiation

determination method

1 reference

8 April 2019

Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

daunorubicin metabolic process

determination method

1 reference

8 April 2019

Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

doxorubicin metabolic process

determination method

1 reference

8 April 2019

Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

lipid metabolism

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

progesterone metabolic process

determination method

1 reference

8 April 2019

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

determination method

1 reference

8 April 2019

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

cellular response to prostaglandin D stimulus

determination method

1 reference

8 April 2019

AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

positive regulation of cell population proliferation

determination method

1 reference

8 April 2019

AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

steroid metabolic process

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

8 April 2019

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52895

determination method

EC enzyme number

1.1.1.357

1 reference

5 January 2016

http://www.uniprot.org/uniprot/P52895.txt?version=160

NADP-dependent oxidoreductase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52895

Aldo/keto reductase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52895

Identifiers

MeSH descriptor ID

subject named as

Aldo-Keto Reductase Family 1 Member C2

0 references

D08.811.682.047.150.700.156.750

0 references

D08.811.682.047.820.284.875

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000370129

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370129

ENSP00000408440

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408440

ENSP00000392694

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000392694

ENSP00000474566

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000474566

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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