WW domain containing E3 ubiquitin protein ligase 2 (Q21105130)

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mammalian protein found in Homo sapiens
  • WWP2
  • AIP2
  • WW domain-containing protein 2
  • atrophin-1 interacting protein 2
  • NEDD4-like E3 ubiquitin-protein ligase WWP2
  • HECT-type E3 ubiquitin transferase WWP2
  • Atrophin-1-interacting protein 2
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Language Label Description Also known as
English
WW domain containing E3 ubiquitin protein ligase 2
mammalian protein found in Homo sapiens
  • WWP2
  • AIP2
  • WW domain-containing protein 2
  • atrophin-1 interacting protein 2
  • NEDD4-like E3 ubiquitin-protein ligase WWP2
  • HECT-type E3 ubiquitin transferase WWP2
  • Atrophin-1-interacting protein 2

Statements

molecular function
ubiquitin-protein transferase activity
determination method
IDA
IEA
IMP
TAS
7 references
retrieved
8 April 2019
stated in
Identification of novel human WW domain-containing proteins by cloning of ligand targets
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
TAS
retrieved
8 April 2019
stated in
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2
GOA
curator
UniProt
UniProt protein ID
O00308
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IEA
retrieved
8 April 2019
stated in
The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination
GOA
curator
UniProt
UniProt protein ID
O00308
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IDA
retrieved
8 April 2019
stated in
WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells
GOA
curator
UniProt
UniProt protein ID
O00308
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IDA
retrieved
8 April 2019
stated in
Protein microarray characterization of the S-nitrosoproteome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IDA
protein binding
determination method
IPI
15 references
retrieved
8 April 2019
stated in
Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins
GOA
curator
UniProt
UniProt protein ID
O00308
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein
GOA
curator
UniProt
UniProt protein ID
O00308
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2
GOA
curator
UniProt
UniProt protein ID
O00308
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways
GOA
curator
UniProt
UniProt protein ID
O00308
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1
GOA
curator
UniProt
UniProt protein ID
O00308
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IPI
cell component
biological process
protein ubiquitination
determination method
IBA
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein
GOA
curator
UniProt
UniProt protein ID
O00308
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O00308
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IEA
retrieved
8 April 2019
stated in
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2
GOA
curator
UniProt
UniProt protein ID
O00308
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IDA
retrieved
8 April 2019
stated in
Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00308
determination method
IBA

Identifiers

 
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