Protein inhibitor of activated STAT 1 (Q21105489)

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mammalian protein found in Homo sapiens

zinc finger, MIZ-type containing 3
GBP
RNA helicase II-binding protein
gu-binding protein
DEAD/H box-binding protein 1
protein inhibitor of activated STAT protein 1
E3 SUMO-protein transferase PIAS1
E3 SUMO-protein ligase PIAS1
DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
PIAS1
AR interacting protein

Language	Label	Description	Also known as
English	Protein inhibitor of activated STAT 1	mammalian protein found in Homo sapiens	zinc finger, MIZ-type containing 3 GBP RNA helicase II-binding protein gu-binding protein DEAD/H box-binding protein 1 protein inhibitor of activated STAT protein 1 E3 SUMO-protein transferase PIAS1 E3 SUMO-protein ligase PIAS1 DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1 PIAS1 AR interacting protein

Statements

1 reference

13 November 2019

UniProt protein ID

SAP domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75925

PINIT domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75925

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75925

Zinc finger, MIZ-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

PINIT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SAP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

transcription corepressor activity

determination method

1 reference

8 April 2019

Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

Negative modulation of androgen receptor transcriptional activity by Daxx

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

zinc ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

transcription factor binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

SUMO ligase activity

determination method

1 reference

8 April 2019

Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

protein binding

determination method

11 references

8 April 2019

SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

A physical interaction network of dengue virus and human proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

SUMOylation of Blimp-1 is critical for plasma cell differentiation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

PIAS1 interacts with FLASH and enhances its co-activation of c-Myb

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

androgen receptor binding

determination method

1 reference

8 April 2019

Negative modulation of androgen receptor transcriptional activity by Daxx

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

determination method

1 reference

8 April 2019

Human cystathionine beta-synthase is a target for sumoylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

protein domain specific binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

SUMO transferase activity

determination method

1 reference

8 April 2019

Transcription factor Sp3 is silenced through SUMO modification by PIAS1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

protein C-terminus binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

determination method

4 references

8 April 2019

Inhibition of Stat1-mediated gene activation by PIAS1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

biological process

androgen receptor signaling pathway

determination method

1 reference

8 April 2019

Negative modulation of androgen receptor transcriptional activity by Daxx

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

receptor signaling pathway via JAK-STAT

determination method

1 reference

8 April 2019

Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

regulation of transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75925&geneProductId=UniProtKB:O75925

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

protein sumoylation

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75925&geneProductId=UniProtKB:O75925

determination method

regulation of interferon-gamma-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

fat cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

visual learning

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

positive regulation of smooth muscle cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

spermatogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

positive regulation of protein sumoylation

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

8 April 2019

SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

protein-DNA complex assembly

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

G1/S transition of mitotic cell cycle

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75925

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75925

Zinc finger, MIZ-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75925

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75925

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000249636

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000249636

ENSP00000438574

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000438574

ENSP00000456558

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000456558

ENSP00000456721

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000456721

ENSP00000457698

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000457698

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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