Matrix metallopeptidase 9 (Q21105703)

Metallopeptidase, catalytic domain superfamily

1 reference

Fibronectin type II domain superfamily

1 reference

PGBD-like superfamily

1 reference

Matrix metalloproteinase-9

1 reference

PGBD superfamily

1 reference

Kringle-like fold

1 reference

Peptidase M10A, catalytic domain, protein family

1 reference

Hemopexin-like domain, protein family

1 reference

Peptidase, metallopeptidase family

1 reference

Fibronectin type II domain, protein family

1 reference

Peptidase M10, metallopeptidase family

1 reference

Peptidoglycan binding-like, protein family

1 reference

Peptidase M10A, cysteine switch, zinc binding site, protein family

1 reference

Hemopexin, conserved site, protein family

1 reference

Hemopexin-like repeats, protein family

1 reference

SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

6 references

8 April 2019

The subject of epidemiology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Extracellular matrix protein 1 inhibits the activity of matrix metalloproteinase 9 through high-affinity protein/protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

In vitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

identical protein binding

IPI

3 references

8 April 2019

Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

In vitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

metallopeptidase activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

endopeptidase activity

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

1 January 2018

Chymase cleavage of stem cell factor yields a bioactive, soluble product

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

1 January 2018

Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

metalloendopeptidase activity

EXP

7 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

metalloendopeptidase activity

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

IBA

endopeptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

serine-type endopeptidase activity

1 reference

8 April 2019

Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum

extracellular exosome

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

tertiary granule lumen

1 reference

8 April 2019

ficolin-1-rich granule lumen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

3 references

4 references

8 April 2019

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

collagen-containing extracellular matrix

IBA

1 reference

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

HDA

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

skeletal system development

HDA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

negative regulation of cation channel activity

1 reference

8 April 2019

Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

positive regulation of protein phosphorylation

1 reference

8 April 2019

Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

endodermal cell differentiation

1 reference

8 April 2019

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

IEP

1 reference

8 April 2019

Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

negative regulation of intrinsic apoptotic signaling pathway

1 reference

8 April 2019

Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

ephrin receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

extracellular matrix disassembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

negative regulation of apoptotic process

1 reference

8 April 2019

Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

macrophage differentiation

1 reference

8 April 2019

SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

positive regulation of keratinocyte migration

1 reference

8 April 2019

Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

positive regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

collagen catabolic process

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

positive regulation of release of cytochrome c from mitochondria

1 reference

8 April 2019

Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

positive regulation of receptor binding

1 reference

8 April 2019

Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

positive regulation of DNA binding

1 reference

8 April 2019

Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

positive regulation of epidermal growth factor receptor signaling pathway

1 reference

8 April 2019

Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

positive regulation of vascular associated smooth muscle cell proliferation

1 reference

8 April 2019

SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

extracellular matrix organization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

positive regulation of cell migration

1 reference

17 October 2017

DDRGK1 regulates NF-κB activity by modulating IκBα stability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14780&geneProductId=UniProtKB:P14780

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

neutrophil degranulation

1 reference

8 April 2019

cellular response to reactive oxygen species

1 reference

8 April 2019

Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

cellular response to cadmium ion

1 reference

8 April 2019

Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

cytokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

collagen catabolic process

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

regulation of neuroinflammatory response

IBA

1 reference

8 April 2019

Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14780

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL440498

has part(s)

Hemopexin-like repeats

1 reference

Peptidase, metallopeptidase

1 reference

Hemopexin, conserved site

1 reference

Peptidoglycan binding-like

1 reference

Hemopexin-like domain

1 reference

fibronectin type II domain

1 reference

Peptidase M10A, cysteine switch, zinc binding site

1 reference

Peptidase M10A, catalytic domain

1 reference

Peptidase M10, metallopeptidase

1 reference

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016