Ring finger protein 41 (Q21106502)

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mammalian protein found in Homo sapiens

fetal liver ring finger
RING finger protein 41
RNF41
ring finger protein 41, E3 ubiquitin protein ligase
RING-type E3 ubiquitin transferase NRDP1
neuregulin receptor degradation protein-1
E3 ubiquitin-protein ligase NRDP1

Language	Label	Description	Also known as
English	Ring finger protein 41	mammalian protein found in Homo sapiens	fetal liver ring finger RING finger protein 41 RNF41 ring finger protein 41, E3 ubiquitin protein ligase RING-type E3 ubiquitin transferase NRDP1 neuregulin receptor degradation protein-1 E3 ubiquitin-protein ligase NRDP1

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H4P4

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H4P4

NRDP1, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H4P4

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

E3 ubiquitin-protein ligase NRDP1, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, SIAH-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

interleukin-3 receptor binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

erythropoietin receptor binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

zinc ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

protein binding

determination method

8 references

8 April 2019

Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

ubiquitin-protein transferase activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

Protein microarray characterization of the S-nitrosoproteome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

protein domain specific binding

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

receptor tyrosine kinase binding

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

endoplasmic reticulum tubular network

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

biological process

regulation of MAPK cascade

determination method

1 reference

8 April 2019

Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

extrinsic apoptotic signaling pathway

determination method

1 reference

8 April 2019

Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

positive regulation of DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

protein polyubiquitination

determination method

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

8 April 2019

Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

regulation of reactive oxygen species metabolic process

determination method

1 reference

8 April 2019

Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

negative regulation of cell migration

determination method

1 reference

8 April 2019

Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

regulation of lymphocyte differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

positive regulation of reactive oxygen species metabolic process

determination method

1 reference

8 April 2019

Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

proteasomal protein catabolic process

determination method

1 reference

8 April 2019

Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

regulation of myeloid cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

regulation of establishment of cell polarity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

negative regulation of cell population proliferation

determination method

1 reference

8 April 2019

Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

protein autoubiquitination

determination method

1 reference

8 April 2019

Protein microarray characterization of the S-nitrosoproteome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

apoptotic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

negative regulation of mitophagy

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

positive regulation of protein catabolic process

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H4P4

determination method

physically interacts with

determination method

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000342755

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000342755

ENSP00000377581

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377581

ENSP00000447303

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447303

ENSP00000484671

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000484671

ENSP00000446595

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446595

ENSP00000448187

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448187

ENSP00000448330

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448330

ENSP00000449575

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449575

ENSP00000450164

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450164

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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