sequestosome 1 (Q21106590)

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mammalian protein found in Homo sapiens
  • sequestosome-1
  • EBI3-associated protein of 60 kDa
  • p60
  • phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
  • autophagy receptor p62
  • EBIAP
  • EBI3-associated protein p60
  • oxidative stress induced like
  • ubiquitin-binding protein p62
  • SQSTM1
  • phosphotyrosine independent ligand for the Lck SH2 domain p62
  • Sequestosome-1 Protein
edit
Language Label Description Also known as
English
sequestosome 1
mammalian protein found in Homo sapiens
  • sequestosome-1
  • EBI3-associated protein of 60 kDa
  • p60
  • phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
  • autophagy receptor p62
  • EBIAP
  • EBI3-associated protein p60
  • oxidative stress induced like
  • ubiquitin-binding protein p62
  • SQSTM1
  • phosphotyrosine independent ligand for the Lck SH2 domain p62
  • Sequestosome-1 Protein

Statements

molecular function
protein binding
determination method
IPI
51 references
retrieved
8 April 2019
stated in
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Disruption of FAT10-MAD2 binding inhibits tumor progression.
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin functions as a scaffold for selective macroautophagy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin functions as a scaffold for selective macroautophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Autophagy mediates degradation of nuclear lamina
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Nix is a selective autophagy receptor for mitochondrial clearance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Global landscape of HIV-human protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Defining the human deubiquitinating enzyme interaction landscape
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
ATM functions at the peroxisome to induce pexophagy in response to ROS.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
identical protein binding
determination method
IEA
IPI
6 references
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin functions as a scaffold for selective macroautophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IEA
cell component
autophagosome
determination method
IBA
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IEA
retrieved
8 April 2019
stated in
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IDA
retrieved
8 April 2019
stated in
MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IDA
retrieved
8 April 2019
stated in
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
GOA
curator
UniProt
UniProt protein ID
Q13501
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IDA
retrieved
8 April 2019
stated in
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IDA
retrieved
8 April 2019
stated in
WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
determination method
IBA
biological process

Identifiers

MeSH descriptor ID
D000071456
subject named as
Sequestosome-1 Protein
0 references
MeSH tree code
D12.644.360.024.329
0 references
D12.776.094.750
0 references
D12.776.157.057.160
0 references
D12.776.476.024.422
0 references
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21106590&oldid=2022928568"