BMX non-receptor tyrosine kinase (Q21106693)

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mammalian protein found in Homo sapiens

ETK
bone marrow tyrosine kinase gene in chromosome X protein
NTK38
epithelial and endothelial tyrosine kinase
Etk/Bmx cytosolic tyrosine kinase
NTK38 tyrosine kinase
cytoplasmic tyrosine-protein kinase BMX
BMX
BTK-like on X chromosome

Language	Label	Description	Also known as
English	BMX non-receptor tyrosine kinase	mammalian protein found in Homo sapiens	ETK bone marrow tyrosine kinase gene in chromosome X protein NTK38 epithelial and endothelial tyrosine kinase Etk/Bmx cytosolic tyrosine kinase NTK38 tyrosine kinase cytoplasmic tyrosine-protein kinase BMX BMX BTK-like on X chromosome

Statements

1 reference

13 November 2019

UniProt protein ID

Cytoplasmic tyrosine-protein kinase BMX

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

BMX, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, Btk motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

signal transducer activity

determination method

1 reference

24 April 2018

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

protein binding

determination method

5 references

8 April 2019

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

8 April 2019

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

8 April 2019

The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

8 April 2019

Phospho-tyrosine dependent protein-protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

protein tyrosine kinase activity

determination method

3 references

signaling receptor binding

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

determination method

2 references

non-membrane spanning protein tyrosine kinase activity

determination method

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

24 April 2018

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

24 April 2018

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

non-membrane spanning protein tyrosine kinase activity

determination method

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

8 April 2019

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

8 April 2019

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

extrinsic component of cytoplasmic side of plasma membrane

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

ruffle membrane

determination method

1 reference

8 April 2019

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

plasma membrane

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

biological process

intracellular signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

NK T cell differentiation

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

regulation of cell population proliferation

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

peptidyl-tyrosine autophosphorylation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

protein autophosphorylation

determination method

1 reference

8 April 2019

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

mesoderm development

determination method

1 reference

8 April 2019

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

innate immune response

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method

signal transduction

determination method

apoptotic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

phosphatidylinositol biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

adaptive immune response

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

B cell receptor signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

tyrosine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

Zinc finger, Btk motif

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

BMX, SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51813

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000308774

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000308774

ENSP00000340082

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000340082

ENSP00000350224

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000350224

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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