coagulation factor II thrombin receptor (Q21106737)

http://www.ebi.ac.uk/interpro/protein/P25116

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

G protein-coupled receptor activity

6 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

27 March 2018

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

signal transducer activity

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

thrombin-activated receptor activity

4 references

27 March 2018

Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

27 March 2018

Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

27 March 2018

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

6 references

8 April 2019

ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

signaling receptor binding

IPI

1 reference

8 April 2019

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

G protein-coupled receptor activity

IPI

6 references

8 April 2019

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

thrombin-activated receptor activity

IBA

5 references

8 April 2019

Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

platelet dense tubular network

IBA

cell component

1 reference

8 April 2019

Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

1 reference

8 April 2019

Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

1 reference

8 April 2019

Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

TAS

postsynaptic membrane

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

neuromuscular junction

1 reference

8 April 2019

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

integral component of plasma membrane

1 reference

27 March 2018

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25116&geneProductId=UniProtKB:P25116

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

1 reference

8 April 2019

Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

1 reference

8 April 2019

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

negative regulation of neuron apoptotic process

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of collagen biosynthetic process

1 reference

8 April 2019

Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

establishment of synaptic specificity at neuromuscular junction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

release of sequestered calcium ion into cytosol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

platelet dense granule organization

1 reference

8 April 2019

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

regulation of sensory perception of pain

IC

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

anatomical structure morphogenesis

1 reference

8 April 2019

Thrombin receptor overexpression in malignant and physiological invasion processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of release of sequestered calcium ion into cytosol

TAS

1 reference

8 April 2019

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

phospholipase C-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

protein kinase C-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

1 reference

8 April 2019

Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

connective tissue replacement involved in inflammatory response wound healing

1 reference

8 April 2019

Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

regulation of blood coagulation

IEP

1 reference

8 April 2019

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

negative regulation of glomerular filtration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of MAPK cascade

1 reference

8 April 2019

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

negative regulation of cell population proliferation

1 reference

8 April 2019

Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of calcium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of Rho protein signal transduction

3 references

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of GTPase activity

1 reference

8 April 2019

Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

cell-cell junction maintenance

IMP

1 reference

8 April 2019

Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

G protein-coupled receptor signaling pathway

IMP

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

positive regulation of receptor signaling pathway via JAK-STAT

1 reference

8 April 2019

Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25116

physically interacts with

NAS

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4047

17 August 2016

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2103856

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25116

Identifiers

MeSH descriptor ID

D044463

subject named as

Receptor, PAR-1

0 references

MeSH tree code

D12.776.395.550.625.800.790

0 references

D12.776.543.550.625.800.790

0 references

D12.776.543.750.695.875.500

0 references

D12.776.543.750.705.675.892.790

0 references

D12.776.543.750.750.850.399

0 references

D12.776.543.750.792.500.500

0 references

D09.400.430.890.625.800.790

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

Guide to Pharmacology Target ID

0 references

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016