thioredoxin reductase 1 (Q21106751)

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mammalian protein found in Homo sapiens

thioredoxin reductase TR1
GRIM-12
TXNRD1
gene associated with retinoic and IFN-induced mortality 12 protein
thioredoxin reductase 1, cytoplasmic
gene associated with retinoic and interferon-induced mortality 12 protein
KM-102-derived reductase-like factor
thioredoxin reductase GRIM-12
testis tissue sperm-binding protein Li 46a
oxidoreductase

Language	Label	Description	Also known as
English	thioredoxin reductase 1	mammalian protein found in Homo sapiens	thioredoxin reductase TR1 GRIM-12 TXNRD1 gene associated with retinoic and IFN-induced mortality 12 protein thioredoxin reductase 1, cytoplasmic gene associated with retinoic and interferon-induced mortality 12 protein KM-102-derived reductase-like factor thioredoxin reductase GRIM-12 testis tissue sperm-binding protein Li 46a oxidoreductase

Statements

1 reference

13 November 2019

UniProt protein ID

Thioredoxin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16881

FAD/NAD-linked reductase, dimerisation domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16881

Thioredoxin/glutathione reductase selenoprotein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16881

FAD/NAD(P)-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16881

FAD/NAD(P)-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Glutaredoxin family

1 reference

based on heuristic

inferred from protein domain or family

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Pyridine nucleotide-disulphide oxidoreductase, class I, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein-disulfide reductase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

methylselenol reductase activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16881&geneProductId=UniProtKB:Q16881

determination method

flavin adenine dinucleotide binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

methylseleninic acid reductase activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16881&geneProductId=UniProtKB:Q16881

determination method

electron transfer activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

thioredoxin-disulfide reductase activity

determination method

6 references

1 January 2018

Human thioredoxin reductase from HeLa cells: selective alkylation of selenocysteine in the protein inhibits enzyme activity and reduction with NADPH influences affinity to heparin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16881&geneProductId=UniProtKB:Q16881

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16881&geneProductId=UniProtKB:Q16881

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16881&geneProductId=UniProtKB:Q16881

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16881&geneProductId=UniProtKB:Q16881

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16881&geneProductId=UniProtKB:Q16881

determination method

1 January 2018

Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16881&geneProductId=UniProtKB:Q16881

determination method

thioredoxin-disulfide reductase activity

determination method

5 references

8 April 2019

Human thioredoxin reductase from HeLa cells: selective alkylation of selenocysteine in the protein inhibits enzyme activity and reduction with NADPH influences affinity to heparin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

extracellular exosome

determination method

1 reference

31 October 2017

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16881&geneProductId=UniProtKB:Q16881

determination method

fibrillar center

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

determination method

3 references

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

biological process

nucleobase-containing small molecule interconversion

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

selenium compound metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

signal transduction

determination method

1 reference

8 April 2019

Human thioredoxin reductase gene localization to chromosomal position 12q23-q24.1 and mRNA distribution in human tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

cellular oxidant detoxification

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

response to oxygen radical

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16881&geneProductId=UniProtKB:Q16881

determination method

regulation of lipid metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

cellular response to oxidative stress

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

mesoderm formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

cell population proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

electron transport chain

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16881

determination method

Identifiers

MeSH descriptor ID

subject named as

Thioredoxin Reductase 1

0 references

D08.811.682.667.750.500

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000421934

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421934

ENSP00000433425

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433425

ENSP00000434516

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434516

ENSP00000434919

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434919

ENSP00000435123

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435123

ENSP00000435929

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435929

ENSP00000347020

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000347020

ENSP00000373506

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373506

ENSP00000380844

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380844

ENSP00000412045

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412045

ENSP00000431294

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000431294

ENSP00000431925

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000431925

ENSP00000432273

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432273

ENSP00000432812

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432812

ENSP00000433507

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433507

ENSP00000433599

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433599

ENSP00000433732

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433732

ENSP00000433887

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433887

ENSP00000433935

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433935

ENSP00000436229

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436229

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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