Folylpolyglutamate synthase (Q21107352)

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mammalian protein found in Homo sapiens

folylpolyglutamate synthase, mitochondrial
FPGS
tetrahydrofolylpolyglutamate synthase
tetrahydrofolate synthase
folylpoly-gamma-glutamate synthetase

Language	Label	Description	Also known as
English	Folylpolyglutamate synthase	mammalian protein found in Homo sapiens	folylpolyglutamate synthase, mitochondrial FPGS tetrahydrofolylpolyglutamate synthase tetrahydrofolate synthase folylpoly-gamma-glutamate synthetase

Statements

1 reference

13 November 2019

UniProt protein ID

Mur ligase, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q05932

Mur-like, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q05932

Folylpolyglutamate synthase, eukaryota

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q05932

Folylpolyglutamate synthetase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

tetrahydrofolylpolyglutamate synthase activity

determination method

7 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

21 June 2018

Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

21 June 2018

Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

21 June 2018

Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

dihydrofolate synthase activity

determination method

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

tetrahydrofolylpolyglutamate synthase activity

determination method

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

determination method

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

21 June 2018

Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

21 June 2018

Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

mitochondrial inner membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

determination method

3 references

21 June 2018

Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

21 June 2018

Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

determination method

3 references

9 May 2019

Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

mitochondrial matrix

determination method

determination method

3 references

9 May 2019

Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

determination method

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

biological process

one-carbon metabolic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

brain development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

folic acid metabolic process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

animal organ regeneration

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

liver development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

glutamate metabolic process

determination method

1 reference

9 May 2019

Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

cell population proliferation

determination method

1 reference

21 June 2018

Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

nucleobase-containing compound metabolic process

determination method

1 reference

9 May 2019

Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

folic acid-containing compound biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

folic acid-containing compound metabolic process

determination method

1 reference

9 May 2019

Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

dihydrofolate biosynthetic process

determination method

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05932&geneProductId=UniProtKB:Q05932

determination method

tetrahydrofolylpolyglutamate biosynthetic process

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05932

determination method

Folylpolyglutamate synthetase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q05932

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000362322

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362322

ENSP00000362344

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362344

ENSP00000377309

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377309

ENSP00000362325

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362325

ENSP00000400007

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000400007

ENSP00000406328

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000406328

ENSP00000486766

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486766

0 references

Sitelinks

Wikipedia(4 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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