Gamma-aminobutyric acid type B receptor subunit 1 (Q21107546)

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mammalian protein found in Homo sapiens

seven transmembrane helix receptor
gamma-aminobutyric acid type B receptor subunit 1
GABA-B receptor, R1 subunit
gamma-aminobutyric acid (GABA) B receptor, 1
GABBR1

Language	Label	Description	Also known as
English	Gamma-aminobutyric acid type B receptor subunit 1	mammalian protein found in Homo sapiens	seven transmembrane helix receptor gamma-aminobutyric acid type B receptor subunit 1 GABA-B receptor, R1 subunit gamma-aminobutyric acid (GABA) B receptor, 1 GABBR1

Statements

1 reference

13 November 2019

UniProt protein ID

Periplasmic binding protein-like I

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBS5

Sushi/SCR/CCP superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBS5

Sushi/SCR/CCP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Receptor, ligand binding region, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR family 3, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

signal transducer activity

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBS5&geneProductId=UniProtKB:Q9UBS5

determination method

protein binding

determination method

5 references

8 April 2019

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

8 April 2019

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

8 April 2019

A comprehensive resource of interacting protein regions for refining human transcription factor networks

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

8 April 2019

Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

G protein-coupled GABA receptor activity

determination method

4 references

16 July 2018

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBS5&geneProductId=UniProtKB:Q9UBS5

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBS5&geneProductId=UniProtKB:Q9UBS5

determination method

16 July 2018

Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBS5&geneProductId=UniProtKB:Q9UBS5

determination method

16 July 2018

Heterodimerization is required for the formation of a functional GABA(B) receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBS5&geneProductId=UniProtKB:Q9UBS5

determination method

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

G protein-coupled GABA receptor activity

determination method

5 references

8 April 2019

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

8 April 2019

Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

8 April 2019

Heterodimerization is required for the formation of a functional GABA(B) receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

G protein-coupled receptor dimeric complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

plasma membrane

determination method

2 references

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

extracellular region

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

G protein-coupled receptor heterodimeric complex

determination method

1 reference

16 July 2018

Heterodimerization is required for the formation of a functional GABA(B) receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBS5&geneProductId=UniProtKB:Q9UBS5

determination method

presynaptic membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

Schaffer collateral - CA1 synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

GABA-ergic synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

biological process

gamma-aminobutyric acid signaling pathway

determination method

3 references

16 July 2018

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBS5&geneProductId=UniProtKB:Q9UBS5

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBS5&geneProductId=UniProtKB:Q9UBS5

determination method

16 July 2018

Heterodimerization is required for the formation of a functional GABA(B) receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBS5&geneProductId=UniProtKB:Q9UBS5

determination method

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

signal transduction

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

negative regulation of adenylate cyclase activity

determination method

1 reference

10 September 2018

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBS5&geneProductId=UniProtKB:Q9UBS5

determination method

regulation of postsynaptic membrane potential

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

gamma-aminobutyric acid signaling pathway

determination method

4 references

8 April 2019

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

8 April 2019

Heterodimerization is required for the formation of a functional GABA(B) receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

neuron-glial cell signaling

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBS5

determination method

physically interacts with

arbaclofen placarbil

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2107312

4-hydroxybutyric acid

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1342

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL301742

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL112797

Receptor, ligand binding region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBS5

sushi/SCR/CCP domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBS5

GPCR family 3, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBS5

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000348248

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000348248

ENSP00000366176

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366176

ENSP00000366211

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366211

ENSP00000366215

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366215

ENSP00000366233

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366233

ENSP00000373029

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373029

ENSP00000373033

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373033

ENSP00000373034

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373034

ENSP00000373035

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373035

ENSP00000373132

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373132

ENSP00000373133

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373133

ENSP00000373134

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373134

ENSP00000373135

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373135

ENSP00000388035

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000388035

ENSP00000391572

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391572

ENSP00000394528

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000394528

ENSP00000399318

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000399318

ENSP00000399861

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000399861

ENSP00000405709

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000405709

ENSP00000406066

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000406066

ENSP00000406285

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000406285

ENSP00000406499

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000406499

ENSP00000408938

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408938

ENSP00000411263

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411263

ENSP00000411286

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411286

ENSP00000412167

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412167

ENSP00000416903

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000416903

ENSP00000419061

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419061

ENSP00000446983

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446983

ENSP00000448531

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448531

ENSP00000448654

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448654

ENSP00000448999

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448999

ENSP00000449342

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449342

ENSP00000449449

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449449

ENSP00000417478

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417478

ENSP00000420602

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420602

ENSP00000416731

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000416731

ENSP00000412044

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412044

ENSP00000417663

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417663

ENSP00000419755

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419755

ENSP00000448763

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448763

ENSP00000417332

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417332

ENSP00000419356

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419356

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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