Lemur tyrosine kinase 2 (Q21107718)

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mammalian protein found in Homo sapiens

serine/threonine-protein kinase KPI-2
kinase/phosphatase/inhibitor 2
CPRK
cyclin-dependent kinase 5/p35-regulated kinase
LMTK2
serine/threonine-protein kinase LMTK2
brain-enriched kinase
protein phosphatase 1, regulatory subunit 100
hBREK
CDK5/p35-regulated kinase
apoptosis-associated tyrosine kinase 2

Language	Label	Description	Also known as
English	Lemur tyrosine kinase 2	mammalian protein found in Homo sapiens	serine/threonine-protein kinase KPI-2 kinase/phosphatase/inhibitor 2 CPRK cyclin-dependent kinase 5/p35-regulated kinase LMTK2 serine/threonine-protein kinase LMTK2 brain-enriched kinase protein phosphatase 1, regulatory subunit 100 hBREK CDK5/p35-regulated kinase apoptosis-associated tyrosine kinase 2

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWU2

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

protein kinase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

kinase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

myosin VI binding

determination method or standard

protein serine/threonine kinase activity

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

8 April 2019

A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

8 April 2019

Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

protein binding

determination method or standard

3 references

8 April 2019

Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

8 April 2019

A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

8 April 2019

A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

protein phosphatase inhibitor activity

determination method or standard

1 reference

8 April 2019

A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

determination method or standard

3 references

8 April 2019

A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

receptor tyrosine kinase

determination method or standard

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU2&geneProductId=UniProtKB:Q8IWU2

determination method or standard

transmembrane signaling receptor activity

determination method or standard

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU2&geneProductId=UniProtKB:Q8IWU2

determination method or standard

transmembrane receptor protein tyrosine kinase activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

recycling endosome

determination method or standard

Golgi apparatus

determination method or standard

1 reference

8 April 2019

Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

determination method or standard

perinuclear region of cytoplasm

determination method or standard

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

determination method or standard

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU2&geneProductId=UniProtKB:Q8IWU2

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

receptor complex

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

biological process

transferrin transport

determination method or standard

phosphorylation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

early endosome to late endosome transport

determination method or standard

1 reference

8 April 2019

BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

receptor recycling

determination method or standard

peptidyl-serine phosphorylation

determination method or standard

1 reference

8 April 2019

Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

endocytic recycling

determination method or standard

1 reference

8 April 2019

Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

protein autophosphorylation

determination method or standard

1 reference

8 April 2019

A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

peptidyl-threonine phosphorylation

determination method or standard

1 reference

8 April 2019

Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

negative regulation of phosphoprotein phosphatase activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

negative regulation of signal transduction

determination method or standard

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU2&geneProductId=UniProtKB:Q8IWU2

determination method or standard

peptidyl-tyrosine phosphorylation

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

cell differentiation

determination method or standard

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU2&geneProductId=UniProtKB:Q8IWU2

determination method or standard

negative regulation of apoptotic process

determination method or standard

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU2&geneProductId=UniProtKB:Q8IWU2

determination method or standard

positive regulation of ERK1 and ERK2 cascade

determination method or standard

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWU2&geneProductId=UniProtKB:Q8IWU2

determination method or standard

transmembrane receptor protein tyrosine kinase signaling pathway

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWU2

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000297293

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000297293

Sitelinks

Wikipedia(0 entries)

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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