Casein kinase 1 alpha 1 (Q21107836)

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mammalian protein found in Homo sapiens

casein kinase I isoform alpha
clock regulator kinase
CK1
epididymis secretory sperm binding protein Li 77p
CKI-alpha
down-regulated in lung cancer
CSNK1A1

Language	Label	Description	Also known as
English	Casein kinase 1 alpha 1	mammalian protein found in Homo sapiens	casein kinase I isoform alpha clock regulator kinase CK1 epididymis secretory sperm binding protein Li 77p CKI-alpha down-regulated in lung cancer CSNK1A1

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48729

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

protein kinase activity

determination method

4 references

1 January 2018

Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

nucleotide binding

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

protein binding

determination method

9 references

1 January 2018

CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

A novel mechanism of keratin cytoskeleton organization through casein kinase Iα and FAM83H in colorectal cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Casein kinase 1alpha interacts with RIP1 and regulates NF-kappaB activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

MDMX regulation of p53 response to ribosomal stress

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

determination method

2 references

kinase activity

determination method

2 references

protein serine/threonine kinase activity

determination method

5 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

17 October 2017

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

17 October 2017

CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

17 October 2017

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

protein serine/threonine kinase activity

determination method

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

determination method

1 reference

1 January 2018

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

mRNA cleavage and polyadenylation specificity factor complex

determination method

1 reference

1 January 2018

CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

determination method

1 reference

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

keratin filament

determination method

1 reference

1 January 2018

A novel mechanism of keratin cytoskeleton organization through casein kinase Iα and FAM83H in colorectal cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

microtubule organizing center

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

chromosome, centromeric region

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

beta-catenin destruction complex

determination method

1 reference

1 January 2018

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

determination method

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

cell projection

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

determination method

1 reference

1 January 2018

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

ribonucleoprotein complex

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

biological process

regulation of GTP binding

determination method

1 reference

1 January 2018

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

Golgi organization

determination method

1 reference

1 January 2018

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

phosphorylation

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

protein phosphorylation

determination method

4 references

1 January 2018

Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

cell surface receptor signaling pathway

determination method

1 reference

1 January 2018

Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

peptidyl-serine phosphorylation

determination method

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

intermediate filament cytoskeleton organization

determination method

1 reference

1 January 2018

A novel mechanism of keratin cytoskeleton organization through casein kinase Iα and FAM83H in colorectal cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

negative regulation of canonical Wnt signaling pathway

determination method

1 reference

17 October 2017

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method

1 reference

17 October 2017

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

signal transduction

determination method

1 reference

1 January 2018

Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

beta-catenin destruction complex assembly

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

regulation of cell shape

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48729&geneProductId=UniProtKB:P48729

determination method

beta-catenin destruction complex disassembly

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

Wnt signaling pathway

determination method

cell morphogenesis

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

peptidyl-serine phosphorylation

determination method

3 references

1 January 2018

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

peptidyl-threonine phosphorylation

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method

negative regulation of canonical Wnt signaling pathway

determination method

3 references

1 January 2018

CKIα ablation highlights a critical role for p53 in invasiveness control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48729

determination method

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48729

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48729

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48729

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000261798

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000261798

ENSP00000367074

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367074

ENSP00000421689

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421689

ENSP00000421268

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421268

ENSP00000425366

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425366

ENSP00000426747

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426747

ENSP00000427031

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427031

ENSP00000430252

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000430252

ENSP00000475319

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000475319

ENSP00000475633

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000475633

ENSP00000475969

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000475969

ENSP00000499284

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499284

ENSP00000499757

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499757

ENSP00000499532

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499532

ENSP00000499647

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499647

ENSP00000499782

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499782

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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