Lysyl oxidase like 2 (Q21107930)

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mammalian protein found in Homo sapiens

lysyl oxidase-related protein WS9-14
lysyl oxidase-like 2 delta e13
lysyl oxidase-like 2 protein
lysyl oxidase homolog 2
lysyl oxidase related 2
lysyl oxidase-related protein 2
lysyl oxidase-like protein 2
LOXL2

Language	Label	Description	Also known as
English	Lysyl oxidase like 2	mammalian protein found in Homo sapiens	lysyl oxidase-related protein WS9-14 lysyl oxidase-like 2 delta e13 lysyl oxidase-like 2 protein lysyl oxidase homolog 2 lysyl oxidase related 2 lysyl oxidase-related protein 2 lysyl oxidase-like protein 2 LOXL2

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

scavenger receptor activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

oligosaccharide binding

determination method

1 reference

9 May 2019

Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

protein-lysine 6-oxidase activity

determination method

4 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

1 January 2018

Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

1 January 2018

LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

1 January 2018

Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

oxidoreductase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

electron transfer activity

determination method

1 reference

9 May 2019

Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

copper ion binding

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

protein-lysine 6-oxidase activity

determination method

6 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

calcium ion binding

determination method

1 reference

9 May 2019

Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

extracellular region

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

extracellular matrix

determination method

1 reference

1 January 2018

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

extracellular space

determination method

3 references

1 January 2018

Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

1 January 2018

Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

determination method

1 reference

9 May 2019

Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

determination method

4 references

9 May 2019

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

endoplasmic reticulum

determination method

1 reference

1 January 2018

LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

extracellular space

determination method

3 references

9 May 2019

Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

biological process

collagen fibril organization

determination method

1 reference

1 January 2018

Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

epithelial to mesenchymal transition

determination method

1 reference

9 May 2019

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

regulation of transcription, DNA-templated

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

endothelial cell migration

determination method

1 reference

9 May 2019

Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

endothelial cell proliferation

determination method

1 reference

9 May 2019

Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

receptor-mediated endocytosis

determination method

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

response to copper ion

determination method

1 reference

9 May 2019

Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

determination method

1 reference

9 May 2019

Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

determination method

1 reference

9 May 2019

Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

sprouting angiogenesis

determination method

1 reference

9 May 2019

Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

transcription, DNA-templated

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4K0&geneProductId=UniProtKB:Q9Y4K0

determination method

electron transport chain

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

positive regulation of epithelial to mesenchymal transition

determination method

1 reference

9 May 2019

Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

peptidyl-lysine oxidation

determination method

heterochromatin organization

determination method

1 reference

9 May 2019

Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

chromatin organization

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

peptidyl-lysine oxidation

determination method

4 references

9 May 2019

LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

vesicle-mediated transport

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4K0

determination method

SRCR-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4K0

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4K0

Lysyl oxidase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4K0

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000373783

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373783

ENSP00000427826

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427826

ENSP00000427883

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427883

ENSP00000427907

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427907

ENSP00000428497

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000428497

ENSP00000428933

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000428933

ENSP00000429778

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429778

ENSP00000430519

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000430519

ENSP00000473322

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473322

Sitelinks

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Multilingual sites(0 entries)

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